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Plek Gene Detail
Summary
  • Symbol
    Plek
  • Name
    pleckstrin
  • Synonyms
    2010300B13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860485
    NCBI Gene: 56193
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:16921206-16958718 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 9.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1167 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860485
 protein coding gene Chr11:16921206-17002381 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018054
 protein coding gene Chr11:14364503-14402930 (-)
A/J MGP_AJ_G0018027
 protein coding gene Chr11:13872825-13910624 (-)
AKR/J MGP_AKRJ_G0017991
 protein coding gene Chr11:14367674-14404573 (-)
BALB/cJ MGP_BALBcJ_G0017995
 protein coding gene Chr11:13989019-14025991 (-)
C3H/HeJ MGP_C3HHeJ_G0017808
 protein coding gene Chr11:14292304-14330656 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018447
 protein coding gene Chr11:14969625-15010841 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016105
 protein coding gene Chr11:13053344-13129241 (-)
CAST/EiJ MGP_CASTEiJ_G0017370
 protein coding gene Chr11:14283273-14366582 (-)
CBA/J MGP_CBAJ_G0017783
 protein coding gene Chr11:15786743-15826380 (-)
DBA/2J MGP_DBA2J_G0017893
 protein coding gene Chr11:13860209-13897053 (-)
FVB/NJ MGP_FVBNJ_G0017885
 protein coding gene Chr11:13649227-13686637 (-)
LP/J MGP_LPJ_G0017964
 protein coding gene Chr11:14528368-14570602 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017911
 protein coding gene Chr11:16235111-16273592 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018488
 protein coding gene Chr11:14450691-14493710 (-)
PWK/PhJ MGP_PWKPhJ_G0017150
 protein coding gene Chr11:13837210-13921872 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016947
 protein coding gene Chr11:14207985-14291679 (-)
WSB/EiJ MGP_WSBEiJ_G0017424
 protein coding gene Chr11:14150915-14185869 (-)



Homology
more
  • Human Ortholog
    PLEK, pleckstrin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEK, pleckstrin
  • Synonyms
    P47, PLEK1
  • Links
    NCBI Gene ID: 5341
    neXtProt AC: NX_P08567
    UniProt: P08567

  • Chr Location
    2p14; chr2:68365282-68397453 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display mild thrombocytopenia, impaired platelet aggregation, and impaired platelet granule secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56193 NCBI Gene Model | MGI Sequence Detail 37513 C57BL/6J ±  kb
transcript NM_019549 RefSeq | MGI Sequence Detail 4117 ZRU/MplStud  
polypeptide Q9JHK5 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1917248
References
more
  • Summaries
    All 27
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:233118 Abdallah BM, et al., DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice. J Bone Miner Res. 2011 Jul;26(7):1457-71
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory