Ptbp2 MGI Mouse Gene Detail - MGI:1860489 - polypyrimidine tract binding protein 2

Symbol

Ptbp2
Name

polypyrimidine tract binding protein 2
Synonyms

brPTB

Feature Type

protein coding gene
IDs

MGI:1860489
NCBI Gene: 56195
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:119512391-119578115 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 52.18 cM
Mapping Data

2 experiments

SNPs within 2kb

1249 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860489	protein coding gene	Chr3:119512390-119578296 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027826	protein coding gene	Chr3:121829388-121900493 (-)
A/J	MGP_AJ_G0027784	protein coding gene	Chr3:117811368-117879700 (-)
AKR/J	MGP_AKRJ_G0027750	protein coding gene	Chr3:120794583-120861897 (-)
BALB/cJ	MGP_BALBcJ_G0027796	protein coding gene	Chr3:117623956-117690539 (-)
C3H/HeJ	MGP_C3HHeJ_G0027527	protein coding gene	Chr3:121188792-121255351 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028242	protein coding gene	Chr3:126270839-126336481 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025581	protein coding gene	Chr3:113315829-113382096 (-)
CAST/EiJ	MGP_CASTEiJ_G0026983	protein coding gene	Chr3:120545982-120613425 (-)
CBA/J	MGP_CBAJ_G0027502	protein coding gene	Chr3:130560632-130633092 (-)
DBA/2J	MGP_DBA2J_G0027643	protein coding gene	Chr3:116985783-117052247 (-)
FVB/NJ	MGP_FVBNJ_G0027611	protein coding gene	Chr3:114596689-114660773 (-)
LP/J	MGP_LPJ_G0027753	protein coding gene	Chr3:123369822-123438606 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027641	protein coding gene	Chr3:138200766-138272528 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028298	protein coding gene	Chr3:120334310-120398619 (-)
PWK/PhJ	MGP_PWKPhJ_G0026709	protein coding gene	Chr3:116621684-116689394 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026532	protein coding gene	Chr3:118389909-118456436 (-)
WSB/EiJ	MGP_WSBEiJ_G0027063	protein coding gene	Chr3:121055993-121125096 (-)

Human Ortholog

PTBP2, polypyrimidine tract binding protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTBP2, polypyrimidine tract binding protein 2
Synonyms

brPTB, nPTB, PTBLP
Links

HGNC:17662

NCBI Gene ID: 58155

neXtProt AC: NX_Q9UKA9

UniProt: Q9UKA9
Chr Location

1p21.3; chr1:96721665-96823739 (+) GRCh38

MGI Vertebrate Homology

Ptbp2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PTBP2
Gene Tree

Ptbp2

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References

1 with disease annotations

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Phenotype Summary

29 phenotypes from 5 alleles in 6 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

48
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

37
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Ptbp2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display neonatal lethality with premature neurogenesis and abnormal neural stem cell polarity.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

932
Tissues

154
cDNA Data

20
Literature Summary

26

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptbp2

ZFIN ptbp2a, ptbp2b

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All Sequences

78
RefSeq

12
UniProt

6
CCDS

CCDS38616.1, CCDS80010.1

Ensembl

ENSMUSG00000028134 (Evidence)
NCBI Gene

56195

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028134	Ensembl Gene Model \| MGI Sequence Detail	65725	C57BL/6J	± kb
transcript	ENSMUST00000029780	Ensembl \| MGI Sequence Detail	3364	Not Applicable
polypeptide	ENSMUSP00000029780	Ensembl \| MGI Sequence Detail	532	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013411 polypyrimidine tract-binding protein 2

(term hierarchy)
InterPro Domains

IPR006536 HnRNP-L/PTB

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR021790 PTBP1-like, RNA recognition motif 2

IPR035002 PTBP2, RNA recognition motif 1

IPR034799 PTBP2, RNA recognition motif 3

IPR034800 PTBP2, RNA recognition motif 4

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

Q91Z31 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 26

cDNA 21

Primer pair 4

Other 1

Microarray probesets 5

Summaries

All 78

Developmental Gene Expression 26

Diseases 1

Gene Ontology 7

Phenotypes 25
Earliest

J:62658 Polydorides AD, et al., A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6350-5
Latest

J:348634 Lin L, et al., Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. Neuron. 2024 Apr 22;

TSS for Ptbp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr35393	Chr3:119577154-119577165 (-)	955 bp
Tssr35392	Chr3:119576911-119576961 (-)	1,179 bp
Tssr35391	Chr3:119576899-119576910 (-)	1,210 bp
Tssr35390	Chr3:119576879-119576890 (-)	1,230 bp
Tssr35389	Chr3:119543631-119543635 (-)	34,482 bp
Tssr35387	Chr3:119536344-119536361 (-)	41,762 bp
Tssr35386	Chr3:119531368-119531372 (-)	46,745 bp
Tssr35385	Chr3:119513740-119513742 (-)	64,374 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24