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Ubr2 Gene Detail
Summary
  • Symbol
    Ubr2
  • Name
    ubiquitin protein ligase E3 component n-recognin 2
  • Synonyms
    9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861099
    NCBI Gene: 224826
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:47239221-47321482 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2704 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861099
 protein coding gene Chr17:47239217-47321812 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023839
 protein coding gene Chr17:48038531-48124518 (-)
A/J MGP_AJ_G0023797
 protein coding gene Chr17:46873429-46954269 (-)
AKR/J MGP_AKRJ_G0023768
 protein coding gene Chr17:47231550-47312337 (-)
BALB/cJ MGP_BALBcJ_G0023801
 protein coding gene Chr17:46773516-46858107 (-)
C3H/HeJ MGP_C3HHeJ_G0023564
 protein coding gene Chr17:47975764-48059156 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024244
 protein coding gene Chr17:50091782-50177356 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021694
 protein coding gene Chr17:43638183-43721262 (-)
CAST/EiJ MGP_CASTEiJ_G0023046
 protein coding gene Chr17:48075137-48159768 (-)
CBA/J MGP_CBAJ_G0023541
 protein coding gene Chr17:51916885-52006250 (-)
DBA/2J MGP_DBA2J_G0023667
 protein coding gene Chr17:45635038-45716633 (-)
FVB/NJ MGP_FVBNJ_G0023634
 protein coding gene Chr17:45268645-45352889 (-)
LP/J MGP_LPJ_G0023748
 protein coding gene Chr17:48712841-48797978 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023663
 protein coding gene Chr17:51435459-51518209 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024289
 protein coding gene Chr17:47595320-47680121 (-)
PWK/PhJ MGP_PWKPhJ_G0022790
 protein coding gene Chr17:44984030-45066774 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022606
 protein coding gene Chr17:44482693-44567489 (-)
WSB/EiJ MGP_WSBEiJ_G0023111
 protein coding gene Chr17:48159425-48244736 (-)



Homology
more
  • Human Ortholog
    UBR2, ubiquitin protein ligase E3 component n-recognin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBR2, ubiquitin protein ligase E3 component n-recognin 2
  • Synonyms
    bA49A4.1, C6orf133, dJ242G1.1, dJ392M17.3
  • Links
    NCBI Gene ID: 23304
    neXtProt AC: NX_Q8IWV8
    UniProt: Q8IWV8

  • Chr Location
    6p21.1; chr6:42564029-42693505 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    3 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
On a mixed genetic background, female homozygotes for a targeted null mutation exhibit embryonic lethality, while males are viable, but sterile due to postnatal testicular degeneration. On an inbred background, both genders die in utero.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    42
  • cDNA Data
    16
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023977 Ensembl Gene Model | MGI Sequence Detail 82262 C57BL/6J ±  kb
    transcript ENSMUST00000113337 Ensembl | MGI Sequence Detail 7633 Not Applicable  
    polypeptide ENSMUSP00000108963 Ensembl | MGI Sequence Detail 1755 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000017013 E3 ubiquitin-protein ligase UBR2
      (term hierarchy)
    • EC
      2.3.2.27
    • InterPro Domains
      IPR003769 Adaptor protein ClpS, core
      IPR042065 E3 ubiquitin-protein ligase ELL-like
      IPR039164 E3 ubiquitin-protein ligase UBR1-like
      IPR047508 E3 ubiquitin-protein ligase UBR2, UBR-box
      IPR044046 E3 ubiquitin-protein ligase UBR-like, C-terminal
      IPR014719 Ribosomal protein bL12, C-terminal/adaptor protein ClpS-like
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR003126 Zinc finger, UBR-type
    • GlyGen
      Q6WKZ8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923986, MGI:1925978, MGI:2139370, MGI:2146871, MGI:3704478
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 4
      Gene Ontology 14
      Phenotypes 20
    • Earliest
      J:62140 Kwon YT, et al., Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway. Mol Cell Biol. 2000 Jun;20(11):4135-48
    • Latest
      J:351183 Shih YC, et al., The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling. Nat Commun. 2024 Jan 15;15(1):532
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory