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Gsk3b Gene Detail
Summary
  • Symbol
    Gsk3b
  • Name
    glycogen synthase kinase 3 beta
  • Synonyms
    7330414F15Rik, 8430431H08Rik, GSK-3, GSK3, GSK-3beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861437
    NCBI Gene: 56637
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:37909363-38066446 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.54 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3303 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861437
 protein coding gene Chr16:37909363-38066446 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022808
 protein coding gene Chr16:36600728-36762245 (+)
A/J MGP_AJ_G0022773
 protein coding gene Chr16:34772561-34940629 (+)
AKR/J MGP_AKRJ_G0022745
 protein coding gene Chr16:36106772-36271509 (+)
BALB/cJ MGP_BALBcJ_G0022774
 protein coding gene Chr16:34895586-35053605 (+)
C3H/HeJ MGP_C3HHeJ_G0022538
 protein coding gene Chr16:36209593-36370484 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023221
 protein coding gene Chr16:37445514-37602467 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020736
 protein coding gene Chr16:35163242-35316158 (+)
CAST/EiJ MGP_CASTEiJ_G0022064
 protein coding gene Chr16:36356603-36521980 (+)
CBA/J MGP_CBAJ_G0022509
 protein coding gene Chr16:39079613-39254184 (+)
DBA/2J MGP_DBA2J_G0022641
 protein coding gene Chr16:34664711-34822284 (+)
FVB/NJ MGP_FVBNJ_G0022616
 protein coding gene Chr16:34696009-34853399 (+)
LP/J MGP_LPJ_G0022709
 protein coding gene Chr16:36284590-36446253 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022635
 protein coding gene Chr16:38208140-38372434 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023236
 protein coding gene Chr16:36060391-36229152 (+)
PWK/PhJ MGP_PWKPhJ_G0021804
 protein coding gene Chr16:35072282-35233873 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021635
 protein coding gene Chr16:35973760-36126601 (+)
WSB/EiJ MGP_WSBEiJ_G0022108
 protein coding gene Chr16:36137717-36299947 (+)



Homology
more
  • Human Ortholog
    GSK3B, glycogen synthase kinase 3 beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSK3B, glycogen synthase kinase 3 beta
  • Links
    NCBI Gene ID: 2932
    neXtProt AC: NX_P49841
    UniProt: P49841

  • Chr Location
    3q13.33; chr3:119821321-120094994 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human GSK3B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 9 alleles in 15 genetic backgrounds
    37 phenotypes from multigenic genotypes
    2 images
    170 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene may die embryonically around mid-gestation or neonatally. When mice die neonatally, cleft palate and sternum are present.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    292
  • GO References
    74
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1371
  • Tissues
    232
  • cDNA Data
    19
  • Literature Summary
    133
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56637 NCBI Gene Model | MGI Sequence Detail 157084 C57BL/6J ±  kb
    transcript NM_001347232 RefSeq | MGI Sequence Detail 8342 C57BL/6  
    polypeptide Q9WV60 UniProt | EBI | MGI Sequence Detail 420 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 20
      Primer pair 8
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1914056, MGI:1925394, MGI:2146721
    References
    more
    • Summaries
      All 653
      Developmental Gene Expression 133
      Gene Ontology 74
      Phenotypes 170
    • Earliest
      J:155370 Cohen JS, Provide fluoxetine information vital to clinicians. J Clin Psychiatry. 1995 Dec;56(12):591
    • Latest
      J:347984 Naillat F, et al., Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory