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Krt71 Gene Detail
Summary
  • Symbol
    Krt71
  • Name
    keratin 71
  • Synonyms
    Ca, Cal4, Cu, Krt2-6g, mK6irs, mK6irs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861586
    NCBI Gene: 56735
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101642384-101651532 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.00 cM
  • Mapping Data
    49 experiments
Strain
Comparison
more
  • SNPs within 2kb
    347 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861586
 protein coding gene Chr15:101642384-101651544 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022384
 protein coding gene Chr15:103862009-103871047 (-)
A/J MGP_AJ_G0022347
 protein coding gene Chr15:99762597-99771752 (-)
AKR/J MGP_AKRJ_G0022322
 protein coding gene Chr15:102792688-102801847 (-)
BALB/cJ MGP_BALBcJ_G0022350
 protein coding gene Chr15:99835288-99844325 (-)
C3H/HeJ MGP_C3HHeJ_G0022117
 protein coding gene Chr15:102871040-102880195 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022799
 protein coding gene Chr15:107716136-107725295 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020322
 protein coding gene Chr15:95573278-95582326 (-)
CAST/EiJ MGP_CASTEiJ_G0021643
 protein coding gene Chr15:103715921-103725038 (-)
CBA/J MGP_CBAJ_G0022086
 protein coding gene Chr15:111474076-111486374 (-)
DBA/2J MGP_DBA2J_G0022217
 protein coding gene Chr15:99074979-99084138 (-)
FVB/NJ MGP_FVBNJ_G0022193
 protein coding gene Chr15:98131291-98140450 (-)
LP/J MGP_LPJ_G0022286
 protein coding gene Chr15:104016386-104027059 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022215
 protein coding gene Chr15:115107661-115116828 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022811
 protein coding gene Chr15:102818043-102827219 (-)
PWK/PhJ MGP_PWKPhJ_G0021383
 protein coding gene Chr15:99218844-99227950 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021215
 protein coding gene Chr15:102664354-102673449 (-)
WSB/EiJ MGP_WSBEiJ_G0021693
 protein coding gene Chr15:103454444-103463599 (-)



Homology
more
  • Human Ortholog
    KRT71, keratin 71
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT71, keratin 71
  • Synonyms
    HYPT13, K6IRS1, KRT6IRS, KRT6IRS1
  • Links
    NCBI Gene ID: 112802
    neXtProt AC: NX_Q3SY84
    UniProt: Q3SY84

  • Chr Location
    12q13.13; chr12:52543909-52553145 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Krt71 mouse models; 1 with human KRT71 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 19 alleles in 19 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 images
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in waved hair and curly vibrissae.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    4
  • cDNA Data
    135
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56735 NCBI Gene Model | MGI Sequence Detail 9149 C57BL/6J ±  kb
    transcript NM_019956 RefSeq | MGI Sequence Detail 2193 Not Specified  
    polypeptide Q9R0H5 UniProt | EBI | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      Genomic 1
      cDNA 137
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1716, MGD-MRK-2251, MGI:2145920, MGI:3044778, MGI:88238
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 8
      Phenotypes 54
    • Earliest
      J:13054 Dunn LC, Caracul, a dominant mutation. J Hered. 1937;28(10):334
    • Latest
      J:337881 Zhang T, et al., Development of Woolly Hair and Hairlessness in a CRISPR-Engineered Mutant Mouse Model with KRT71 Mutations. Cells. 2023 Jul 5;12(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory