Nme6 MGI Mouse Gene Detail - MGI:1861676 - NME/NM23 nucleoside diphosphate kinase 6

Symbol

Nme6
Name

NME/NM23 nucleoside diphosphate kinase 6
Synonyms

nm23-M6, non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)

Feature Type

protein coding gene
IDs

MGI:1861676
NCBI Gene: 54369
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:109661830-109672042 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.79 cM
Mapping Data

2 experiments

SNPs within 2kb

552 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861676	protein coding gene	Chr9:109661817-109672184 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035337	protein coding gene	Chr9:111927758-111937733 (+)
A/J	MGP_AJ_G0035318	protein coding gene	Chr9:107880813-107891473 (+)
AKR/J	MGP_AKRJ_G0035249	protein coding gene	Chr9:110553660-110563976 (+)
BALB/cJ	MGP_BALBcJ_G0035313	protein coding gene	Chr9:107618323-107629572 (+)
C3H/HeJ	MGP_C3HHeJ_G0035021	protein coding gene	Chr9:111017776-111027924 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035835	protein coding gene	Chr9:114971292-114983505 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032721	protein coding gene	Chr9:105117811-105127943 (+)
CAST/EiJ	MGP_CASTEiJ_G0034327	protein coding gene	Chr9:110830783-110842415 (+)
CBA/J	MGP_CBAJ_G0034988	protein coding gene	Chr9:119239840-119251726 (+)
DBA/2J	MGP_DBA2J_G0035147	protein coding gene	Chr9:107342400-107353032 (+)
FVB/NJ	MGP_FVBNJ_G0035094	protein coding gene	Chr9:106170733-106180534 (+)
LP/J	MGP_LPJ_G0035226	protein coding gene	Chr9:112240825-112250833 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035134	protein coding gene	Chr9:120612302-120624137 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035855	protein coding gene	Chr9:110851068-110862783 (+)
PWK/PhJ	MGP_PWKPhJ_G0034034	protein coding gene	Chr9:107562879-107573206 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033869	protein coding gene	Chr9:110935667-110948412 (+)
WSB/EiJ	MGP_WSBEiJ_G0034448	protein coding gene	Chr9:110742064-110753057 (+)

Human Ortholog

NME6, NME/NM23 nucleoside diphosphate kinase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NME6, NME/NM23 nucleoside diphosphate kinase 6
Synonyms

IPIA-ALPHA, NDK 6, NM23-H6
Links

HGNC:20567

NCBI Gene ID: 10201

neXtProt AC: NX_O75414

UniProt: O75414
Chr Location

3p21.31; chr3:48288402-48301685 (-) GRCh38

MGI Vertebrate Homology

Nme6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NME6
Gene Tree

Nme6

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Gene trapped

7
Targeted

4
Find Mice (IMSR)

21 strains or lines available

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

849
Tissues

131
cDNA Data

60
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nme6

ZFIN nme6

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All Sequences

76
RefSeq

24
UniProt

5
CCDS

CCDS23558.1

Ensembl

ENSMUSG00000032478 (Evidence)
NCBI Gene

54369

			Length	Strain/Species	Flank
genomic	54369	NCBI Gene Model \| MGI Sequence Detail	10213	C57BL/6J	± kb
transcript	NM_001409696	RefSeq \| MGI Sequence Detail	1198	C57BL/6
polypeptide	O88425	UniProt \| EBI \| MGI Sequence Detail	189	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000023366 nucleoside diphosphate kinase

(term hierarchy)
EC

2.7.4.6
InterPro Domains

IPR001564 Nucleoside diphosphate kinase

IPR037994 Nucleoside diphosphate kinase 6

IPR023005 Nucleoside diphosphate kinase, active site

IPR034907 Nucleoside diphosphate kinase-like domain

IPR036850 Nucleoside diphosphate kinase-like domain superfamily

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All nucleic 62

cDNA 61

Primer pair 1

Microarray probesets 3

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 13
Earliest

J:62651 Mehus JG, et al., NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. Hum Genet. 1999 Jun;104(6):454-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nme6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87247	Chr9:109661824-109661870 (+)	17 bp
Tssr87248	Chr9:109662066-109662126 (+)	266 bp
Tssr87249	Chr9:109662127-109662141 (+)	304 bp
Tssr87250	Chr9:109662203-109662225 (+)	384 bp
Tssr87251	Chr9:109662231-109662269 (+)	420 bp
Tssr87252	Chr9:109662285-109662294 (+)	460 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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