Cited4 MGI Mouse Gene Detail - MGI:1861694 - Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4

Symbol

Cited4
Name

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
Synonyms

Mrg2

Feature Type

protein coding gene
IDs

MGI:1861694
NCBI Gene: 56222
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr4:120523769-120525017 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 56.52 cM
Mapping Data

4 experiments

SNPs within 2kb

100 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861694	protein coding gene	Chr4:120523760-120525017 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028712	protein coding gene	Chr4:121939771-121941019 (+)
A/J	MGP_AJ_G0028672	protein coding gene	Chr4:117142256-117143504 (+)
AKR/J	MGP_AKRJ_G0028625	protein coding gene	Chr4:119709847-119711095 (+)
BALB/cJ	MGP_BALBcJ_G0028695	protein coding gene	Chr4:117750276-117751524 (+)
C3H/HeJ	MGP_C3HHeJ_G0028410	protein coding gene	Chr4:121241859-121243107 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029136	protein coding gene	Chr4:126543845-126545093 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026413	protein coding gene	Chr4:111199703-111200948 (+)
CAST/EiJ	MGP_CASTEiJ_G0027841	protein coding gene	Chr4:118607232-118608480 (+)
CBA/J	MGP_CBAJ_G0028377	protein coding gene	Chr4:129970644-129971892 (+)
DBA/2J	MGP_DBA2J_G0028524	protein coding gene	Chr4:117717482-117718730 (+)
FVB/NJ	MGP_FVBNJ_G0028490	protein coding gene	Chr4:116240904-116242152 (+)
LP/J	MGP_LPJ_G0028624	protein coding gene	Chr4:122072263-122073511 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028518	protein coding gene	Chr4:134804213-134805461 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029173	protein coding gene	Chr4:120778841-120780089 (+)
PWK/PhJ	MGP_PWKPhJ_G0027564	protein coding gene	Chr4:114660593-114661841 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027390	protein coding gene	Chr4:117216289-117217539 (+)
WSB/EiJ	MGP_WSBEiJ_G0027921	protein coding gene	Chr4:120796637-120797885 (+)

Human Ortholog

CITED4, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CITED4, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
Links

HGNC:18696

NCBI Gene ID: 163732

neXtProt AC: NX_Q96RK1

UniProt: Q96RK1
Chr Location

1p34.2; chr1:40861054-40862363 (-) GRCh38

MGI Vertebrate Homology

Cited4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CITED4
Gene Tree

Cited4

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Radiation induced

1
Targeted

7
Genomic Mutations

4 involving Cited4
Incidental Mutations

CvDC
Find Mice (IMSR)

7 strains or lines available

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

894
Tissues

127
cDNA Data

52
Literature Summary

15

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cited4

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All Sequences

41
RefSeq

2
UniProt

2
CCDS

CCDS18592.1

Ensembl

ENSMUSG00000070803 (Evidence)
NCBI Gene

56222

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070803	Ensembl Gene Model \| MGI Sequence Detail	1249	C57BL/6J	± kb
transcript	ENSMUST00000094814	Ensembl \| MGI Sequence Detail	1249	Not Applicable
polypeptide	ENSMUSP00000092408	Ensembl \| MGI Sequence Detail	182	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005507 Cbp/p300-interacting transactivator 4

(term hierarchy)
InterPro Domains

IPR007576 CITED

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All nucleic 59

cDNA 54

Primer pair 5

Microarray probesets 5

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MGI:2140450, MGI:2144584

Summaries

All 60

Developmental Gene Expression 15

Gene Ontology 4

Phenotypes 18
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cited4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38800	Chr4:120523759-120523776 (+)	-1 bp
Tssr38801	Chr4:120523811-120523820 (+)	47 bp
Tssr38802	Chr4:120524132-120524140 (+)	367 bp
Tssr38803	Chr4:120524356-120524369 (+)	594 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24