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Necab3 Gene Detail
Summary
  • Symbol
    Necab3
  • Name
    N-terminal EF-hand calcium binding protein 3
  • Synonyms
    2900010M17Rik, Apba2bp, Nip1, XB51
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861721
    NCBI Gene: 56846
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:154386319-154400810 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 76.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    377 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861721
 protein coding gene Chr2:154386311-154401326 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026716
 protein coding gene Chr2:159299830-159314350 (-)
A/J MGP_AJ_G0026682
 protein coding gene Chr2:152944307-152958965 (-)
AKR/J MGP_AKRJ_G0026653
 protein coding gene Chr2:157395690-157414617 (-)
BALB/cJ MGP_BALBcJ_G0026691
 protein coding gene Chr2:153242016-153256484 (-)
C3H/HeJ MGP_C3HHeJ_G0026434
 protein coding gene Chr2:157753972-157769572 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027140
 protein coding gene Chr2:163950449-163964899 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024510
 protein coding gene Chr2:146474176-146488806 (-)
CAST/EiJ MGP_CASTEiJ_G0025895
 protein coding gene Chr2:158070344-158084900 (-)
CBA/J MGP_CBAJ_G0026411
 protein coding gene Chr2:169911934-169929596 (-)
DBA/2J MGP_DBA2J_G0026548
 protein coding gene Chr2:152163690-152178157 (-)
FVB/NJ MGP_FVBNJ_G0026515
 protein coding gene Chr2:150550919-150566533 (-)
LP/J MGP_LPJ_G0026653
 protein coding gene Chr2:159417891-159432697 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026536
 protein coding gene Chr2:173961704-173977519 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027196
 protein coding gene Chr2:157270547-157285009 (-)
PWK/PhJ MGP_PWKPhJ_G0025629
 protein coding gene Chr2:151652850-151667417 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025432
 protein coding gene Chr2:156229779-156245319 (-)
WSB/EiJ MGP_WSBEiJ_G0025965
 protein coding gene Chr2:158192505-158208491 (-)



Homology
more
  • Human Ortholog
    NECAB3, N-terminal EF-hand calcium binding protein 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NECAB3, N-terminal EF-hand calcium binding protein 3
  • Synonyms
    APBA2BP, dJ63M2.4, dJ63M2.5, EFCBP3, NIP1, STIP3, SYTIP2, XB51
  • Links
    NCBI Gene ID: 63941
    neXtProt AC: NX_Q96P71
    UniProt: Q96P71

  • Chr Location
    20q11.22; chr20:33657087-33675348 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    7
  • cDNA Data
    11
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027489 Ensembl Gene Model | MGI Sequence Detail 14492 C57BL/6J ±  kb
transcript ENSMUST00000000895 Ensembl | MGI Sequence Detail 1829 Not Applicable  
polypeptide ENSMUSP00000000895 Ensembl | MGI Sequence Detail 353 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 4
Other
Accession IDs
less
MGI:1920134, MGI:2139094
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 4
  • Earliest
    J:63596 Lee DS, et al., Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. J Biol Chem. 2000 Jul 28;275(30):23134-8
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory