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Gabarap Gene Detail
Summary
  • Symbol
    Gabarap
  • Name
    gamma-aminobutyric acid receptor associated protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861742
    NCBI Gene: 56486
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr11:69882196-69885775 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.95 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861742
 protein coding gene Chr11:69881969-69885777 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018575
 protein coding gene Chr11:70485723-70491833 (+)
A/J MGP_AJ_G0018543
 protein coding gene Chr11:67816148-67819862 (+)
AKR/J MGP_AKRJ_G0018512
 protein coding gene Chr11:69837502-69841074 (+)
BALB/cJ MGP_BALBcJ_G0018515
 protein coding gene Chr11:68144691-68148453 (+)
C3H/HeJ MGP_C3HHeJ_G0018328
 protein coding gene Chr11:69875561-69879960 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018966
 protein coding gene Chr11:72607983-72611713 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016611
 protein coding gene Chr11:64740485-64744004 (+)
CAST/EiJ MGP_CASTEiJ_G0017883
 protein coding gene Chr11:70119177-70122730 (+)
CBA/J MGP_CBAJ_G0018300
 protein coding gene Chr11:75867346-75870924 (+)
DBA/2J MGP_DBA2J_G0018410
 protein coding gene Chr11:67400638-67404203 (+)
FVB/NJ MGP_FVBNJ_G0018400
 protein coding gene Chr11:67048106-67051503 (+)
LP/J MGP_LPJ_G0018480
 protein coding gene Chr11:71066850-71070428 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018423
 protein coding gene Chr11:76455527-76460722 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019008
 protein coding gene Chr11:70110335-70114975 (+)
PWK/PhJ MGP_PWKPhJ_G0017657
 protein coding gene Chr11:68052073-68057046 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017447
 protein coding gene Chr11:69928012-69931656 (+)
WSB/EiJ MGP_WSBEiJ_G0017937
 protein coding gene Chr11:69774465-69780447 (+)



Homology
more
  • Human Ortholog
    GABARAP, GABA type A receptor-associated protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABARAP, GABA type A receptor-associated protein
  • Synonyms
    ATG8A, GABARAP-a, MM46
  • Links
    NCBI Gene ID: 11337
    neXtProt AC: NX_O95166
    UniProt: O95166

  • Chr Location
    17p13.1; chr17:7240008-7242449 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    20 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    5
  • Targeted
    5
  • Genomic Mutations
    2 involving Gabarap
  • Find Mice (IMSR)
    22 strains or lines available
Mice homozygous for a disruption in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    2
  • cDNA Data
    242
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56486 NCBI Gene Model | MGI Sequence Detail 3580 C57BL/6J ±  kb
transcript NM_019749 RefSeq | MGI Sequence Detail 1122 ZRU/MplStud  
polypeptide Q9DCD6 UniProt | EBI | MGI Sequence Detail 117 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 242
    cDNA 242

    Microarray probesets 3
References
more
  • Summaries
    All 66
    Developmental Gene Expression 2
    Gene Ontology 16
    Phenotypes 20
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:329331 Li J, et al., RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss. Dev Cell. 2022 Sep 26;57(18):2204-2220.e6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory