About   Help   FAQ
Nsmf Gene Detail
Summary
  • Symbol
    Nsmf
  • Name
    NMDA receptor synaptonuclear signaling and neuronal migration factor
  • Synonyms
    Jacob, Nelf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861755
    NCBI Gene: 56876
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:24944370-24952893 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 16.94 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861755
 protein coding gene Chr2:24944367-24952893 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025418
 protein coding gene Chr2:22904185-22912711 (+)
A/J MGP_AJ_G0025395
 protein coding gene Chr2:22017502-22026028 (+)
AKR/J MGP_AKRJ_G0025365
 protein coding gene Chr2:22769345-22777871 (+)
BALB/cJ MGP_BALBcJ_G0025391
 protein coding gene Chr2:22139565-22148087 (+)
C3H/HeJ MGP_C3HHeJ_G0025152
 protein coding gene Chr2:22699070-22707592 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025835
 protein coding gene Chr2:23639763-23648289 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023246
 protein coding gene Chr2:20952056-20960576 (+)
CAST/EiJ MGP_CASTEiJ_G0024615
 protein coding gene Chr2:22582419-22590944 (+)
CBA/J MGP_CBAJ_G0025130
 protein coding gene Chr2:24469907-24478429 (+)
DBA/2J MGP_DBA2J_G0025263
 protein coding gene Chr2:21875533-21884059 (+)
FVB/NJ MGP_FVBNJ_G0025225
 protein coding gene Chr2:21613743-21622274 (+)
LP/J MGP_LPJ_G0025349
 protein coding gene Chr2:22855467-22863989 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025256
 protein coding gene Chr2:24685722-24694248 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025894
 protein coding gene Chr2:22712689-22721211 (+)
PWK/PhJ MGP_PWKPhJ_G0024363
 protein coding gene Chr2:21682640-21691204 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024163
 protein coding gene Chr2:22861286-22869837 (+)
WSB/EiJ MGP_WSBEiJ_G0024684
 protein coding gene Chr2:22786269-22794793 (+)



Homology
more
  • Human Ortholog
    NSMF, NMDA receptor synaptonuclear signaling and neuronal migration factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NSMF, NMDA receptor synaptonuclear signaling and neuronal migration factor
  • Synonyms
    HH9, NELF
  • Links
    NCBI Gene ID: 26012
    neXtProt AC: NX_Q6X4W1
    UniProt: Q6X4W1

  • Chr Location
    9q34.3; chr9:137447570-137459334 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human NSMF associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit delayed sexual maturation in female mice and reduced male and female fertility. Another null allee shows hippocampal dysplasia with reduced synapses and simplification of dendrites, reduced LTP, and deficits in hippocampus-dependent learning. Females have fewer ovarian follicles and prolonged metestrus but shorter diestrus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    796
  • Tissues
    56
  • cDNA Data
    82
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56876 NCBI Gene Model | MGI Sequence Detail 8524 C57BL/6J ±  kb
    transcript NR_185326 RefSeq | MGI Sequence Detail 3201 C57BL/6  
    polypeptide Q99NF2 UniProt | EBI | MGI Sequence Detail 532 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000011136 nasal embryonic luteinizing hormone-releasing hormone factor
      (term hierarchy)
    • InterPro Domains
      IPR000048 IQ motif, EF-hand binding site
      IPR033374 NMDA receptor synaptonuclear signalling and neuronal migration factor
    • GlyGen
      Q99NF2 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 85
      Primer pair 1
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:63404 Kramer PR, et al., Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons. Genes Dev. 2000 Jul 15;14(14):1824-34
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory