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Htr3b Gene Detail
Summary
  • Symbol
    Htr3b
  • Name
    5-hydroxytryptamine (serotonin) receptor 3B
  • Synonyms
    5-HT3B, 5-HT3 receptor subunit B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861899
    NCBI Gene: 57014
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr9:48846308-48876290 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 26.54 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    785 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861899
 protein coding gene Chr9:48846308-48876290 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034766
 protein coding gene Chr9:47729660-47758987 (-)
A/J MGP_AJ_G0034747
 protein coding gene Chr9:46318368-46347821 (-)
AKR/J MGP_AKRJ_G0034675
 protein coding gene Chr9:47281047-47312033 (-)
BALB/cJ MGP_BALBcJ_G0034739
 protein coding gene Chr9:46040085-46070108 (-)
C3H/HeJ MGP_C3HHeJ_G0034449
 protein coding gene Chr9:47740093-47769440 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035259
 protein coding gene Chr9:49094600-49127041 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032172
 protein coding gene Chr9:45811512-45841805 (-)
CAST/EiJ MGP_CASTEiJ_G0033771
 protein coding gene Chr9:47685556-47716246 (-)
CBA/J MGP_CBAJ_G0034421
 protein coding gene Chr9:50834272-50865892 (-)
DBA/2J MGP_DBA2J_G0034580
 protein coding gene Chr9:46174477-46206311 (-)
FVB/NJ MGP_FVBNJ_G0034521
 protein coding gene Chr9:45424227-45453705 (-)
LP/J MGP_LPJ_G0034661
 protein coding gene Chr9:48104533-48139121 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034565
 protein coding gene Chr9:52525645-52556625 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035280
 protein coding gene Chr9:47222296-47252365 (-)
PWK/PhJ MGP_PWKPhJ_G0033476
 protein coding gene Chr9:46139690-46169944 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033311
 protein coding gene Chr9:47536984-47570373 (-)
WSB/EiJ MGP_WSBEiJ_G0033884
 protein coding gene Chr9:47257033-47289088 (-)



Homology
more
  • Human Ortholog
    HTR3B, 5-hydroxytryptamine receptor 3B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR3B, 5-hydroxytryptamine receptor 3B
  • Synonyms
    5-HT3B
  • Links
    NCBI Gene ID: 9177
    neXtProt AC: NX_O95264
    UniProt: O95264

  • Chr Location
    11q23.2; chr11:113898923-113949079 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HTR3B associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    26
  • cDNA Data
    4
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57014 NCBI Gene Model | MGI Sequence Detail 29983 C57BL/6J ±  kb
    transcript NM_020274 RefSeq | MGI Sequence Detail 2411 C57BL/6  
    polypeptide Q9JHJ5 UniProt | EBI | MGI Sequence Detail 437 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008834 5-hydroxytryptamine receptor 3B
      (term hierarchy)
    • InterPro Domains
      IPR008132 5-hydroxytryptamine 3 receptor
      IPR008134 5-hydroxytryptamine 3 receptor, B subunit
      IPR049944 5-hydroxytryptamine 3 receptor, transmembrane domain
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    • GlyGen
      Q9JHJ5 4 sites
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 4
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:62799 Hanna MC, et al., Evidence for expression of heteromeric serotonin 5-HT(3) receptors in rodents. J Neurochem. 2000 Jul;75(1):240-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory