Ltb4r2 MGI Mouse Gene Detail - MGI:1888501

Symbol

Ltb4r2
Name

leukotriene B4 receptor 2
Synonyms

5830462O07Rik, BLT2

Feature Type

protein coding gene
IDs

MGI:1888501
NCBI Gene: 57260
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr14:55998885-56002595 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

124 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888501	protein coding gene	Chr14:55995379-56002595 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021369	protein coding gene	Chr14:49803861-49805662 (+)
A/J	MGP_AJ_G0021328	protein coding gene	Chr14:48814918-48816719 (+)
AKR/J	MGP_AKRJ_G0021304	protein coding gene	Chr14:50566416-50568217 (+)
BALB/cJ	MGP_BALBcJ_G0021332	protein coding gene	Chr14:48780882-48782683 (+)
C3H/HeJ	MGP_C3HHeJ_G0021112	protein coding gene	Chr14:50255984-50257785 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021770	protein coding gene	Chr14:52301148-52302949 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019317	protein coding gene	Chr14:47184002-47185790 (+)
CAST/EiJ	MGP_CASTEiJ_G0020631	protein coding gene	Chr14:46514369-46516170 (+)
CBA/J	MGP_CBAJ_G0021079	protein coding gene	Chr14:53864710-53866511 (+)
DBA/2J	MGP_DBA2J_G0021200	protein coding gene	Chr14:48534811-48536612 (+)
FVB/NJ	MGP_FVBNJ_G0021182	protein coding gene	Chr14:47982669-47984470 (+)
LP/J	MGP_LPJ_G0021274	protein coding gene	Chr14:50855974-50857775 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021206	protein coding gene	Chr14:53223516-53225317 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021797	protein coding gene	Chr14:49748038-49749839 (+)
PWK/PhJ	MGP_PWKPhJ_G0020378	protein coding gene	Chr14:45068760-45070561 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020206	protein coding gene	Chr14:45753734-45755535 (+)
WSB/EiJ	MGP_WSBEiJ_G0020684	protein coding gene	Chr14:50032405-50034206 (+)

Human Ortholog

LTB4R2, leukotriene B4 receptor 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LTB4R2, leukotriene B4 receptor 2
Synonyms

BLT2, BLTR2, JULF2, KPG_004, LTB4-R 2, LTB4-R2, NOP9
Links

HGNC:19260

NCBI Gene ID: 56413

neXtProt AC: NX_Q9NPC1

UniProt: Q9NPC1
Chr Location

14q12; chr14:24305734-24312053 (+) GRCh38

MGI Vertebrate Homology

Ltb4r2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LTB4R2
Gene Tree

Ltb4r2

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Phenotype Summary

5 phenotypes from 2 alleles in 3 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

2 involving Ltb4r2
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced incidence and severity of autoantibody-induced inflammatory arthritis and decreased susceptibility to IgE antigen-dependent passive cutaneous anaphylaxis.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ltb4r2

ZFIN ltb4r2a, ltb4r2b

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All Sequences

37
RefSeq

8
UniProt

1
CCDS

CCDS27128.1

Ensembl

ENSMUSG00000040432 (Evidence)
NCBI Gene

57260

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040432	Ensembl Gene Model \| MGI Sequence Detail	3711	C57BL/6J	± kb
transcript	ENSMUST00000044554	Ensembl \| MGI Sequence Detail	1439	Not Applicable
polypeptide	ENSMUSP00000048358	Ensembl \| MGI Sequence Detail	360	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001595 leukotriene B4 receptor 2

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR003981 Leukotriene B4 receptor

IPR003982 Leukotriene B4 type 2 receptor
GlyGen

Q9JJL9 1 site

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All nucleic 5

cDNA 5

Microarray probesets 2

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MGI:1923327

Summaries

All 48

Gene Ontology 6

Phenotypes 20
Earliest

J:63822 Yokomizo T, et al., A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders [see comments]. J Exp Med. 2000 Aug 7;192(3):421-32
Latest

J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11

TSS for Ltb4r2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125813	Chr14:55998842-55998858 (+)	-35 bp
Tssr125814	Chr14:55998865-55998893 (+)	-6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24