Retnlb MGI Mouse Gene Detail - MGI:1888505

Symbol

Retnlb
Name

resistin like beta
Synonyms

9030012B21Rik, Fizz2, Relmb, RELMbeta, Xcp3

Feature Type

protein coding gene
IDs

MGI:1888505
NCBI Gene: 57263
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr16:48637219-48639255 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 30.75 cM, cytoband B5
Mapping Data

3 experiments

SNPs within 2kb

164 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888505	protein coding gene	Chr16:48637219-48639255 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022867	protein coding gene	Chr16:47696373-47698410 (+)
A/J	MGP_AJ_G0022833	protein coding gene	Chr16:45596881-45598916 (+)
AKR/J	MGP_AKRJ_G0022805	protein coding gene	Chr16:47113847-47115882 (+)
BALB/cJ	MGP_BALBcJ_G0022834	protein coding gene	Chr16:45641327-45643362 (+)
C3H/HeJ	MGP_C3HHeJ_G0022597	protein coding gene	Chr16:47207677-47209696 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023281	protein coding gene	Chr16:48876736-48878771 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020794	protein coding gene	Chr16:45722805-45724834 (+)
CAST/EiJ	MGP_CASTEiJ_G0022123	protein coding gene	Chr16:47480000-47482057 (+)
CBA/J	MGP_CBAJ_G0022570	protein coding gene	Chr16:50803816-50805835 (+)
DBA/2J	MGP_DBA2J_G0022701	protein coding gene	Chr16:45310476-45312511 (+)
FVB/NJ	MGP_FVBNJ_G0022677	protein coding gene	Chr16:45204485-45206510 (+)
LP/J	MGP_LPJ_G0022769	protein coding gene	Chr16:47447663-47449698 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022695	protein coding gene	Chr16:50485598-50487633 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023296	protein coding gene	Chr16:47112149-47114184 (+)
PWK/PhJ	MGP_PWKPhJ_G0021863	protein coding gene	Chr16:45665055-45667074 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021693	protein coding gene	Chr16:47001922-47003962 (+)
WSB/EiJ	MGP_WSBEiJ_G0022168	protein coding gene	Chr16:47161777-47163801 (+)

Human Ortholog

RETNLB, resistin like beta

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RETNLB, resistin like beta
Synonyms

FIZZ1, FIZZ2, HXCP2, RELMb, RELM-beta, RELMbeta, XCP2
Links

HGNC:20388

NCBI Gene ID: 84666

neXtProt AC: NX_Q9BQ08

UniProt: Q9BQ08
Chr Location

3q13.13; chr3:108743424-108757410 (-) GRCh38

MGI Vertebrate Homology

Retnlb stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RETNLB
Gene Tree

Retnlb

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Phenotype Summary

26 phenotypes from 3 alleles in 5 genetic backgrounds
2 images
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene on a C57BL/6 background provides protection from DSS-induced colitis while on an FVB/N background, mice are more susceptible to AOM/DSS-induced colon tumors.

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All GO Annotations

5
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

21
cDNA Data

87
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

3
CCDS

CCDS28210.1

Ensembl

ENSMUSG00000022650 (Evidence)
NCBI Gene

57263

			Length	Strain/Species	Flank
genomic	57263	NCBI Gene Model \| MGI Sequence Detail	2037	C57BL/6J	± kb
transcript	NM_023881	RefSeq \| MGI Sequence Detail	718	ZRU/MplStud
polypeptide	Q99P86	UniProt \| EBI \| MGI Sequence Detail	105	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013897 resistin-like beta

(term hierarchy)
PDB

1RH7
InterPro Domains

IPR009714 Resistin-like molecule hormone family

IPR036262 Resistin-like superfamily

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All nucleic 89

cDNA 87

Primer pair 1

Other 1

Microarray probesets 3

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MGI:1925319

Summaries

All 50

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 17
Earliest

J:63867 Holcomb IN, et al., FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000 Aug 1;19(15):4046-55
Latest

J:321566 Mihi B, et al., Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration. Cell Rep Med. 2021 Jun 15;2(6):100320

TSS for Retnlb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138678	Chr16:48637324-48637339 (+)	113 bp
Tssr138679	Chr16:48639238-48639261 (+)	2,031 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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