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Brd4 Gene Detail
Summary
  • Symbol
    Brd4
  • Name
    bromodomain containing 4
  • Synonyms
    HUNK1, MCAP, WI-11513
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888520
    NCBI Gene: 57261
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:32415248-32503696 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.39 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1424 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888520
 protein coding gene Chr17:32415246-32503717 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023500
 protein coding gene Chr17:32025874-32120413 (-)
A/J MGP_AJ_G0023457
 protein coding gene Chr17:30962747-31052357 (-)
AKR/J MGP_AKRJ_G0023423
 protein coding gene Chr17:31253417-31340783 (-)
BALB/cJ MGP_BALBcJ_G0023462
 protein coding gene Chr17:31057985-31148058 (-)
C3H/HeJ MGP_C3HHeJ_G0023224
 protein coding gene Chr17:31640723-31734963 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023905
 protein coding gene Chr17:33113885-33211095 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021379
 protein coding gene Chr17:28068112-28156901 (-)
CAST/EiJ MGP_CASTEiJ_G0022725
 protein coding gene Chr17:31679595-31789203 (-)
CBA/J MGP_CBAJ_G0023199
 protein coding gene Chr17:34549259-34666406 (-)
DBA/2J MGP_DBA2J_G0023329
 protein coding gene Chr17:30341120-30431228 (-)
FVB/NJ MGP_FVBNJ_G0023299
 protein coding gene Chr17:30166242-30256802 (-)
LP/J MGP_LPJ_G0023407
 protein coding gene Chr17:32242017-32343083 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023317
 protein coding gene Chr17:33634304-33731724 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023947
 protein coding gene Chr17:31601412-31693174 (-)
PWK/PhJ MGP_PWKPhJ_G0022474
 protein coding gene Chr17:29233684-29324150 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022293
 protein coding gene Chr17:29621291-29713662 (-)
WSB/EiJ MGP_WSBEiJ_G0022787
 protein coding gene Chr17:31588461-31680183 (-)



Homology
more
  • Human Ortholog
    BRD4, bromodomain containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRD4, bromodomain containing 4
  • Synonyms
    CAP, CDLS6, FSHRG4, HUNK1, HUNKI, MCAP
  • Links
    NCBI Gene ID: 23476
    neXtProt AC: NX_O60885
    UniProt: O60885

  • Chr Location
    19p13.12; chr19:15235519-15332545 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Brd4 mouse models; 3 with human BRD4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 3 alleles in 3 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene-trap null mutation die soon after implantation. Heterozygotes exhibit impaired pre- and postnatal growth, head malformations, lack of subcutaneous fat, cataracts, and abnormal liver cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    80
  • cDNA Data
    14
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024002 Ensembl Gene Model | MGI Sequence Detail 88449 C57BL/6J ±  kb
    transcript ENSMUST00000003726 Ensembl | MGI Sequence Detail 5957 Not Applicable  
    polypeptide ENSMUSP00000003726 Ensembl | MGI Sequence Detail 1401 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 15
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1337084
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 16
      Phenotypes 28
    • Earliest
      J:50546 Resch K, et al., Homology between human chromosome 2p13.3 and the wobbler critical region on mouse chromosome 11: comparative high-resolution mapping of STS and EST loci on YAC/BAC contigs. Mamm Genome. 1998 Nov;9(11):893-8
    • Latest
      J:357409 Padmanabhan A, et al., A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation. Nat Cardiovasc Res. 2024 Mar;3(3):317-331
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory