Xpo4 MGI Mouse Gene Detail - MGI:1888526

Symbol

Xpo4
Name

exportin 4
Synonyms

B430309A01Rik, mKIAA1721

Feature Type

protein coding gene
IDs

MGI:1888526
NCBI Gene: 57258
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:57814978-57902887 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 30.11 cM, cytoband C2
Mapping Data

2 experiments

SNPs within 2kb

1493 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888526	protein coding gene	Chr14:57814978-57906951 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021409	protein coding gene	Chr14:51778548-51873026 (-)
A/J	MGP_AJ_G0021370	protein coding gene	Chr14:50748689-50835369 (-)
AKR/J	MGP_AKRJ_G0021345	protein coding gene	Chr14:52533989-52621798 (-)
BALB/cJ	MGP_BALBcJ_G0021373	protein coding gene	Chr14:50694247-50781663 (-)
C3H/HeJ	MGP_C3HHeJ_G0021152	protein coding gene	Chr14:52180206-52268676 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021812	protein coding gene	Chr14:54333051-54418213 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019352	protein coding gene	Chr14:48826965-48911914 (-)
CAST/EiJ	MGP_CASTEiJ_G0020670	protein coding gene	Chr14:48515657-48602795 (-)
CBA/J	MGP_CBAJ_G0021119	protein coding gene	Chr14:55948744-56046099 (-)
DBA/2J	MGP_DBA2J_G0021240	protein coding gene	Chr14:50422253-50507691 (-)
FVB/NJ	MGP_FVBNJ_G0021221	protein coding gene	Chr14:49811965-49898637 (-)
LP/J	MGP_LPJ_G0021315	protein coding gene	Chr14:52821123-52910013 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021249	protein coding gene	Chr14:55293726-55387518 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021836	protein coding gene	Chr14:51682395-51773179 (-)
PWK/PhJ	MGP_PWKPhJ_G0020413	protein coding gene	Chr14:46963749-47049740 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020246	protein coding gene	Chr14:47746723-47837902 (-)
WSB/EiJ	MGP_WSBEiJ_G0020722	protein coding gene	Chr14:51995007-52084675 (-)

Human Ortholog

XPO4, exportin 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

XPO4, exportin 4
Synonyms

exp4
Links

HGNC:17796

NCBI Gene ID: 64328

neXtProt AC: NX_Q9C0E2

UniProt: Q9C0E2
Chr Location

13q12.11; chr13:20777329-20903048 (-) GRCh38

MGI Vertebrate Homology

Xpo4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: XPO4
Gene Tree

Xpo4

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Phenotype Summary

21 phenotypes from 3 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Targeted

2
Genomic Mutations

1 involving Xpo4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

85 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality before E10.5. Heterozygotes show male infertility, increased DNA damage in testes and the hippocampus, decrease in hippocampal neurons and impaired spatial memory. Mice homozygous for a gene trapped allele appear phenotypically normal.

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

27
cDNA Data

69
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase xpo4

ZFIN xpo4

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All Sequences

60
RefSeq

12
UniProt

5
CCDS

CCDS56961.1

Ensembl

ENSMUSG00000021952 (Evidence)
NCBI Gene

57258

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021952	Ensembl Gene Model \| MGI Sequence Detail	87910	C57BL/6J	± kb
transcript	ENSMUST00000174545	Ensembl \| MGI Sequence Detail	8680	Not Applicable
polypeptide	ENSMUSP00000133280	Ensembl \| MGI Sequence Detail	1151	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017498 exportin-4

(term hierarchy)
PDB

5DLQ
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR014877 Exportin-1, C-terminal

IPR044189 Exportin 4/7-like
GlyGen

Q9ESJ0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 69

cDNA 69

Microarray probesets 5

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MGI:1925792

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 14
Earliest

J:63907 Lipowsky G, et al., Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. EMBO J. 2000 Aug 15;19(16):4362-71
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Xpo4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128974	Chr14:57902649-57902717 (-)	204 bp
Tssr128973	Chr14:57902411-57902452 (-)	455 bp
Tssr128972	Chr14:57902383-57902391 (-)	500 bp
Tssr128971	Chr14:57899673-57899681 (-)	3,210 bp
Tssr128970	Chr14:57836073-57836074 (-)	66,813 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24