Icmt MGI Mouse Gene Detail - MGI:1888594 - isoprenylcysteine carboxyl methyltransferase

Symbol

Icmt
Name

isoprenylcysteine carboxyl methyltransferase
Synonyms

1700008E11Rik, Gm13095, HSTE14, pcCMT, prenylated protein carboxyl methyltransferase, prenylcysteine carboxyl methyltransferase, protein-S isoprenylcysteine O-methyltransferase, STE14

Feature Type

protein coding gene
IDs

MGI:1888594
NCBI Gene: 57295
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr4:152381684-152391578 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 83.02 cM
Mapping Data

2 experiments

SNPs within 2kb

331 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888594	protein coding gene	Chr4:152381671-152391583 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029178	protein coding gene	Chr4:156408132-156418007 (+)
A/J	MGP_AJ_G0029143	protein coding gene	Chr4:149856344-149866238 (+)
AKR/J	MGP_AKRJ_G0029091	protein coding gene	Chr4:153926261-153936155 (+)
BALB/cJ	MGP_BALBcJ_G0029159	protein coding gene	Chr4:150322608-150332502 (+)
C3H/HeJ	MGP_C3HHeJ_G0028880	protein coding gene	Chr4:154492403-154502297 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029608	protein coding gene	Chr4:162022778-162032672 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026854	protein coding gene	Chr4:142196542-142206700 (+)
CAST/EiJ	MGP_CASTEiJ_G0028293	protein coding gene	Chr4:151844836-151854669 (+)
CBA/J	MGP_CBAJ_G0028842	protein coding gene	Chr4:166855658-166865538 (+)
DBA/2J	MGP_DBA2J_G0028991	protein coding gene	Chr4:149908739-149918633 (+)
FVB/NJ	MGP_FVBNJ_G0028955	protein coding gene	Chr4:149069175-149079069 (+)
LP/J	MGP_LPJ_G0029081	protein coding gene	Chr4:156334648-156344542 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028982	protein coding gene	Chr4:169863711-169873605 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029640	protein coding gene	Chr4:154465557-154475451 (+)
PWK/PhJ	MGP_PWKPhJ_G0028013	protein coding gene	Chr4:145975769-145985836 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027847	protein coding gene	Chr4:148752634-148762483 (+)
WSB/EiJ	MGP_WSBEiJ_G0028373	protein coding gene	Chr4:154651725-154661602 (+)

Human Ortholog

ICMT, isoprenylcysteine carboxyl methyltransferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ICMT, isoprenylcysteine carboxyl methyltransferase
Synonyms

HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT
Links

HGNC:5350

NCBI Gene ID: 23463

neXtProt AC: NX_O60725

UniProt: O60725
Chr Location

1p36.31; chr1:6221193-6235972 (-) GRCh38

MGI Vertebrate Homology

Icmt stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ICMT
Gene Tree

Icmt

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Phenotype Summary

19 phenotypes from 3 alleles in 5 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

2
Gene trapped

4
Targeted

8
Genomic Mutations

3 involving Icmt
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Targeted null mutations result in reduced embryo size and death by E12. At E10.5, embryos homozygous for one null allele show severe anemia, extensive apoptosis in the neural tube and forebrain region, and liver agenesis due to a dramatic delay in albumin induction and failed hepatocyte outgrowth.

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All GO Annotations

30
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

825
Tissues

109
cDNA Data

130
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase icmt

ZFIN icmt

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All Sequences

57
RefSeq

8
UniProt

3
CCDS

CCDS18998.1

Ensembl

ENSMUSG00000039662 (Evidence)
NCBI Gene

57295

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039662	Ensembl Gene Model \| MGI Sequence Detail	9895	C57BL/6J	± kb
transcript	ENSMUST00000048892	Ensembl \| MGI Sequence Detail	4919	Not Applicable
polypeptide	ENSMUSP00000043390	Ensembl \| MGI Sequence Detail	284	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008884 protein-S-isoprenylcysteine O-methyltransferase

(term hierarchy)
EC

2.1.1.100
InterPro Domains

IPR007269 Isoprenylcysteine carboxyl methyltransferase

IPR025770 Protein-S-isoprenylcysteine O-methyltransferase

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All nucleic 135

cDNA 131

Primer pair 2

Other 2

Microarray probesets 3

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MGI:1916534, MGI:2140687, MGI:3723264

Summaries

All 55

Developmental Gene Expression 4

Gene Ontology 12

Phenotypes 21
Earliest

J:60194 Lin X, et al., Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1 [see comments]. Nat Neurosci. 2000 Feb;3(2):157-63
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Icmt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40538	Chr4:152380623-152380637 (+)	-1,054 bp
Tssr40539	Chr4:152380657-152380678 (+)	-1,016 bp
Tssr40540	Chr4:152381662-152381677 (+)	-14 bp
Tssr40541	Chr4:152381707-152381712 (+)	26 bp
Tssr40542	Chr4:152381717-152381730 (+)	40 bp
Tssr40543	Chr4:152381731-152381783 (+)	73 bp
Tssr40544	Chr4:152381786-152381825 (+)	122 bp
Tssr40545	Chr4:152381946-152381957 (+)	268 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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