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St3gal6 Gene Detail
Summary
  • Symbol
    St3gal6
  • Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 6
  • Synonyms
    1700023B24Rik, Siat10, ST3Gal VI
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888707
    NCBI Gene: 54613
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:58290105-58344614 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 34.58 cM, cytoband C1.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1661 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888707
 protein coding gene Chr16:58288488-58344614 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022902
 protein coding gene Chr16:57633678-57693749 (-)
A/J MGP_AJ_G0022869
 protein coding gene Chr16:55178545-55235518 (-)
AKR/J MGP_AKRJ_G0022841
 protein coding gene Chr16:56907477-56967043 (-)
BALB/cJ MGP_BALBcJ_G0022869
 protein coding gene Chr16:55270883-55328742 (-)
C3H/HeJ MGP_C3HHeJ_G0022632
 protein coding gene Chr16:57125258-57185894 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023317
 protein coding gene Chr16:59254509-59317770 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020828
 protein coding gene Chr16:54739920-54795828 (-)
CAST/EiJ MGP_CASTEiJ_G0022159
 protein coding gene Chr16:57457091-57519023 (-)
CBA/J MGP_CBAJ_G0022605
 protein coding gene Chr16:61618029-61680574 (-)
DBA/2J MGP_DBA2J_G0022737
 protein coding gene Chr16:54911829-54967766 (-)
FVB/NJ MGP_FVBNJ_G0022712
 protein coding gene Chr16:54661583-54717425 (-)
LP/J MGP_LPJ_G0022804
 protein coding gene Chr16:57416022-57483379 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022730
 protein coding gene Chr16:61977176-62035838 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023332
 protein coding gene Chr16:57041222-57098902 (-)
PWK/PhJ MGP_PWKPhJ_G0021898
 protein coding gene Chr16:55215079-55271608 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021728
 protein coding gene Chr16:56817106-56873820 (-)
WSB/EiJ MGP_WSBEiJ_G0022203
 protein coding gene Chr16:57079468-57135096 (-)



Homology
more
  • Human Ortholog
    ST3GAL6, ST3 beta-galactoside alpha-2,3-sialyltransferase 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST3GAL6, ST3 beta-galactoside alpha-2,3-sialyltransferase 6
  • Synonyms
    SIAT10, ST3GALVI
  • Links
    NCBI Gene ID: 10402
    neXtProt AC: NX_Q9Y274
    UniProt: Q9Y274

  • Chr Location
    3q12.1; chr3:98732236-98821201 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit modest impairment in leukocyte rolling and neutrophil recruitment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    110
  • cDNA Data
    18
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54613 NCBI Gene Model | MGI Sequence Detail 54510 C57BL/6J ±  kb
transcript NM_018784 RefSeq | MGI Sequence Detail 2506 C57BL/6  
polypeptide Q8VIB3 UniProt | EBI | MGI Sequence Detail 329 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 9
Other
Accession IDs
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MGI:1922763, MGI:2146521, MGI:2146659
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:64092 Kapitonov D, et al., Combinatorial PCR approach to homology-based cloning: cloning and expression of mouse and human GM3-synthase. Glycoconj J. 1999 Jul;16(7):337-50
  • Latest
    J:341196 Yang WH, et al., Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis. iScience. 2023 Oct 20;26(10):107883
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory