Pf4 MGI Mouse Gene Detail - MGI:1888711

Symbol

Pf4
Name

platelet factor 4
Synonyms

Cxcl4, Pf4, Scyb4

Feature Type

protein coding gene
IDs

MGI:1888711
NCBI Gene: 56744
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:90920362-90921242 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 44.78 cM
Mapping Data

2 experiments

SNPs within 2kb

69 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888711	protein coding gene	Chr5:90920294-90921242 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029728	protein coding gene	Chr5:91863337-91864285 (+)
A/J	MGP_AJ_G0029694	protein coding gene	Chr5:88237092-88238040 (+)
AKR/J	MGP_AKRJ_G0029640	protein coding gene	Chr5:91099386-91100334 (+)
BALB/cJ	MGP_BALBcJ_G0029704	protein coding gene	Chr5:89138048-89138996 (+)
C3H/HeJ	MGP_C3HHeJ_G0029427	protein coding gene	Chr5:91518017-91518965 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030158	protein coding gene	Chr5:95535337-95536285 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027394	protein coding gene	Chr5:83941714-83942666 (+)
CAST/EiJ	MGP_CASTEiJ_G0028837	protein coding gene	Chr5:90890752-90891699 (+)
CBA/J	MGP_CBAJ_G0029397	protein coding gene	Chr5:98807414-98808362 (+)
DBA/2J	MGP_DBA2J_G0029541	protein coding gene	Chr5:88311817-88312765 (+)
FVB/NJ	MGP_FVBNJ_G0029500	protein coding gene	Chr5:87171812-87172760 (+)
LP/J	MGP_LPJ_G0029629	protein coding gene	Chr5:92241967-92242915 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029529	protein coding gene	Chr5:103790742-103791690 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030192	protein coding gene	Chr5:90640609-90641557 (+)
PWK/PhJ	MGP_PWKPhJ_G0028556	protein coding gene	Chr5:87370699-87371647 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028391	protein coding gene	Chr5:90058646-90059590 (+)
WSB/EiJ	MGP_WSBEiJ_G0028916	protein coding gene	Chr5:91099375-91100323 (+)

Human Ortholog

PF4, platelet factor 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PF4, platelet factor 4
Synonyms

CXCL4, PF-4, SCYB4
Links

HGNC:8861

NCBI Gene ID: 5196

neXtProt AC: NX_P02776

UniProt: P02776
Chr Location

4q13.3; chr4:73980811-73982124 (-) GRCh38

Human Ortholog

PF4V1, platelet factor 4 variant 1
Synonyms

CXCL4L1, CXCL4V1, PF4A, PF4-ALT, SCYB4V1
Links

HGNC:8862

NCBI Gene ID: 5197

neXtProt AC: NX_P10720

UniProt: P10720
Chr Location

4q13.3; chr4:73853296-73854483 (+) GRCh38

MGI Vertebrate Homology

Pf4 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PF4, PF4V1
Gene Tree

Pf4

Diseases

1 with human PF4 associations

				Human Disease	Mouse Models
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

6
Radiation induced

1
Spontaneous

1
Targeted

5
Genomic Mutations

4 involving Pf4
Find Mice (IMSR)

16 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous and heterozygous null mice display increased platelet counts and reduced thrombus formation following vascular injury.

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All GO Annotations

39
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

892
Tissues

50
cDNA Data

32
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

2
UniProt

4
CCDS

CCDS19416.1

Ensembl

ENSMUSG00000029373 (Evidence)
NCBI Gene

56744

			Length	Strain/Species	Flank
genomic	56744	NCBI Gene Model \| MGI Sequence Detail	881	C57BL/6J	± kb
transcript	NM_019932	RefSeq \| MGI Sequence Detail	520	C57BL/6
polypeptide	Q9Z126	UniProt \| EBI \| MGI Sequence Detail	105	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012569 platelet factor 4

(term hierarchy)
InterPro Domains

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

IPR001089 CXC chemokine

IPR018048 CXC chemokine, conserved site

IPR033899 CXC Chemokine domain
GlyGen

Q9Z126 1 site

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All nucleic 39

cDNA 32

Primer pair 6

Other 1

Microarray probesets 3

Summaries

All 99

Developmental Gene Expression 14

Gene Ontology 9

Phenotypes 46
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:341634 Pokrajac NT, et al., Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation. Dev Cell. 2023 Oct 23;58(20):2015-2031.e8

TSS for Pf4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47187	Chr5:90919484-90919489 (+)	-875 bp
Tssr47188	Chr5:90919919-90919930 (+)	-437 bp
Tssr47189	Chr5:90920328-90920339 (+)	-28 bp
Tssr47190	Chr5:90920352-90920368 (+)	-2 bp
Tssr47191	Chr5:90920396-90920410 (+)	41 bp
Tssr47192	Chr5:90921046-90921059 (+)	691 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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