Ppbp MGI Mouse Gene Detail - MGI:1888712 - pro-platelet basic protein

Symbol

Ppbp
Name

pro-platelet basic protein
Synonyms

2400003M24Rik, beta-TG, b-TG1, CTAP3, CTAPIII, Cxcl7, LA-PF4, LDGF, MDGF, NAP-2, NAP-2, NAP-2-L1, Scyb7, TGB, TGB1, THBGB1

Feature Type

protein coding gene
IDs

MGI:1888712
NCBI Gene: 57349
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr5:90916377-90917922 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 44.78 cM
Mapping Data

3 experiments

SNPs within 2kb

66 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888712	protein coding gene	Chr5:90916377-90917922 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029727	protein coding gene	Chr5:91859426-91860971 (+)
A/J	MGP_AJ_G0029693	protein coding gene	Chr5:88233175-88234720 (+)
AKR/J	MGP_AKRJ_G0029639	protein coding gene	Chr5:91095469-91097014 (+)
BALB/cJ	MGP_BALBcJ_G0029703	protein coding gene	Chr5:89134150-89135693 (+)
C3H/HeJ	MGP_C3HHeJ_G0029426	protein coding gene	Chr5:91514111-91515654 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030157	protein coding gene	Chr5:95531422-95532967 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027393	protein coding gene	Chr5:83937701-83939244 (+)
CAST/EiJ	MGP_CASTEiJ_G0028836	protein coding gene	Chr5:90886834-90888377 (+)
CBA/J	MGP_CBAJ_G0029396	protein coding gene	Chr5:98803503-98805046 (+)
DBA/2J	MGP_DBA2J_G0029540	protein coding gene	Chr5:88307923-88309466 (+)
FVB/NJ	MGP_FVBNJ_G0029499	protein coding gene	Chr5:87167901-87169444 (+)
LP/J	MGP_LPJ_G0029628	protein coding gene	Chr5:92238056-92239601 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029528	protein coding gene	Chr5:103786846-103788389 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030191	protein coding gene	Chr5:90636702-90638247 (+)
PWK/PhJ	MGP_PWKPhJ_G0028555	protein coding gene	Chr5:87366693-87368238 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028390	protein coding gene	Chr5:90054703-90056249 (+)
WSB/EiJ	MGP_WSBEiJ_G0028915	protein coding gene	Chr5:91095461-91097006 (+)

Human Ortholog

PPBP, pro-platelet basic protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPBP, pro-platelet basic protein
Synonyms

Beta-TG, B-TG1, CTAP3, CTAP-III, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1
Links

HGNC:9240

NCBI Gene ID: 5473

neXtProt AC: NX_P02775

UniProt: P02775
Chr Location

4q13.3; chr4:73986439-73988190 (-) GRCh38

MGI Vertebrate Homology

Ppbp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPBP
Gene Tree

Ppbp

Diseases

1 with human PPBP associations

				Human Disease	Mouse Models
				clear cell renal cell carcinoma IDs clear cell renal cell carcinoma DOID:4467 MESH:D002292 NCI:C4033 UMLS_CUI:C0279702

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

4 involving Ppbp
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired leukocyte shape change and migration following vascular injury.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

785
Tissues

30
cDNA Data

21
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

2
UniProt

1
CCDS

CCDS19415.1

Ensembl

ENSMUSG00000029372 (Evidence)
NCBI Gene

57349

			Length	Strain/Species	Flank
genomic	57349	NCBI Gene Model \| MGI Sequence Detail	1546	C57BL/6J	± kb
transcript	NM_023785	RefSeq \| MGI Sequence Detail	1098	C57BL/6
polypeptide	NP_076274	RefSeq \| MGI Sequence Detail	113	C57BL/6

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UniProt

1 Sequence
InterPro Domains

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

IPR001089 CXC chemokine

IPR033899 CXC Chemokine domain

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All nucleic 22

cDNA 21

Primer pair 1

Microarray probesets 3

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MGI:1922842, MGI:2141003

Summaries

All 52

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ppbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47179	Chr5:90916335-90916355 (+)	-32 bp
Tssr47180	Chr5:90916370-90916385 (+)	1 bp
Tssr1545	Chr5:90916392-90916403 (+)	21 bp
Tssr47181	Chr5:90916492-90916505 (+)	122 bp
Tssr47182	Chr5:90916539-90916546 (+)	166 bp
Tssr47183	Chr5:90917310-90917323 (+)	940 bp
Tssr47184	Chr5:90917453-90917465 (+)	1,082 bp
Tssr47185	Chr5:90917552-90917563 (+)	1,181 bp
Tssr47186	Chr5:90917709-90917718 (+)	1,337 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24