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Septin6 Gene Detail
Summary
  • Symbol
    Septin6
  • Name
    septin 6
  • Synonyms
    2810035H17Rik, C920001C06Rik, Sept6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888939
    NCBI Gene: 56526
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:36174925-36253711 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 21.32 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1239 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888939
 protein coding gene ChrX:36174925-36255447 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035628
 protein coding gene ChrX:31848325-31934982 (-)
A/J MGP_AJ_G0035605
 protein coding gene ChrX:31904542-31985199 (-)
AKR/J MGP_AKRJ_G0035538
 protein coding gene ChrX:32627062-32716332 (-)
BALB/cJ MGP_BALBcJ_G0035598
 protein coding gene ChrX:31644197-31726380 (-)
C3H/HeJ MGP_C3HHeJ_G0035316
 protein coding gene ChrX:32161967-32244097 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036134
 protein coding gene ChrX:32483536-32566196 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032996
 protein coding gene ChrX:30132346-30211757 (-)
CAST/EiJ MGP_CASTEiJ_G0034606
 protein coding gene ChrX:20318937-20403410 (-)
CBA/J MGP_CBAJ_G0035285
 protein coding gene ChrX:33331687-33417028 (-)
DBA/2J MGP_DBA2J_G0035436
 protein coding gene ChrX:31731578-31817689 (-)
FVB/NJ MGP_FVBNJ_G0035383
 protein coding gene ChrX:31504995-31586538 (-)
LP/J MGP_LPJ_G0035518
 protein coding gene ChrX:32202401-32282091 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035427
 protein coding gene ChrX:33794365-33879119 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036141
 protein coding gene ChrX:31812956-31897555 (-)
PWK/PhJ MGP_PWKPhJ_G0034308
 protein coding gene ChrX:19781420-19865855 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034149
 protein coding gene ChrX:20804899-20886494 (-)
WSB/EiJ MGP_WSBEiJ_G0034742
 protein coding gene ChrX:31613044-31696314 (-)



Homology
more
  • Human Ortholog
    SEPTIN6, septin 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEPTIN6, septin 6
  • Synonyms
    SEP2, SEPT2, SEPT6, Septin-6
  • Links
    NCBI Gene ID: 23157
    neXtProt AC: NX_Q14141
    UniProt: Q14141

  • Chr Location
    Xq24; chrX:119615724-119693370 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous females and hemizygous males harboring a knock-out mutation in this gene have a normal lifespan and display neither gross abnormalities, changes in cytokinesis, nor spontaneous malignancies including leukemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    49
  • cDNA Data
    20
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56526 NCBI Gene Model | MGI Sequence Detail 78787 C57BL/6J ±  kb
    transcript NM_001253706 RefSeq | MGI Sequence Detail 4737 C57BL/6  
    polypeptide Q9R1T4 UniProt | EBI | MGI Sequence Detail 434 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1919926, MGI:2443232, MGI:6368835
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:65529 Kinoshita A, et al., Differential localization of septins in the mouse brain. J Comp Neurol. 2000 Dec 11;428(2):223-39
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory