Fmnl1 MGI Mouse Gene Detail - MGI:1888994

Symbol

Fmnl1
Name

formin-like 1
Synonyms

8030453N10Rik, formin-related gene in leukocytes

Feature Type

protein coding gene
IDs

MGI:1888994
NCBI Gene: 57778
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr11:103061933-103089727 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 66.71 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

649 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888994	protein coding gene	Chr11:103061401-103089727 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019258	protein coding gene	Chr11:106226999-106256470 (+)
A/J	MGP_AJ_G0019226	protein coding gene	Chr11:101719027-101747675 (+)
AKR/J	MGP_AKRJ_G0019195	protein coding gene	Chr11:104853530-104881334 (+)
BALB/cJ	MGP_BALBcJ_G0019200	protein coding gene	Chr11:102185900-102214453 (+)
C3H/HeJ	MGP_C3HHeJ_G0019009	protein coding gene	Chr11:105081409-105109166 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019649	protein coding gene	Chr11:109532707-109560386 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017275	protein coding gene	Chr11:99128656-99156079 (+)
CAST/EiJ	MGP_CASTEiJ_G0018563	protein coding gene	Chr11:106095214-106128854 (+)
CBA/J	MGP_CBAJ_G0018978	protein coding gene	Chr11:114085173-114114480 (+)
DBA/2J	MGP_DBA2J_G0019090	protein coding gene	Chr11:101226164-101253879 (+)
FVB/NJ	MGP_FVBNJ_G0019080	protein coding gene	Chr11:100769865-100798123 (+)
LP/J	MGP_LPJ_G0019159	protein coding gene	Chr11:106738692-106766437 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019111	protein coding gene	Chr11:113462323-113492617 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019687	protein coding gene	Chr11:105238102-105265924 (+)
PWK/PhJ	MGP_PWKPhJ_G0018326	protein coding gene	Chr11:102297751-102326522 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018118	protein coding gene	Chr11:104989314-105016621 (+)
WSB/EiJ	MGP_WSBEiJ_G0018612	protein coding gene	Chr11:105234924-105263977 (+)

Human Ortholog

FMNL1, formin like 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FMNL1, formin like 1
Synonyms

C17orf1, C17orf1B, FHOD4, FMNL, KW-13
Links

HGNC:1212

NCBI Gene ID: 752

neXtProt AC: NX_O95466

UniProt: O95466
Chr Location

17q21.31; chr17:45221444-45247319 (+) GRCh38

MGI Vertebrate Homology

Fmnl1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FMNL1
Gene Tree

Fmnl1

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Phenotype Summary

11 phenotypes from 2 alleles in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Targeted

6
Genomic Mutations

1 involving Fmnl1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available

One constitutive homozygous KO allele is embryonic lethal, another is viable but leads to impaired T cell trafficking to inflammation sites. Conditional homozygous KO in myeloid cells leads to reduced macrophage migration and podosome formation.

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All GO Annotations

21
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

20
cDNA Data

7
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fmnl1

ZFIN fmnl1a, fmnl1b

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All Sequences

68
RefSeq

24
UniProt

5
CCDS

CCDS36348.1, CCDS36349.1

Ensembl

ENSMUSG00000055805 (Evidence)
NCBI Gene

57778

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055805	Ensembl Gene Model \| MGI Sequence Detail	27795	C57BL/6J	± kb
transcript	ENSMUST00000218163	Ensembl \| MGI Sequence Detail	3824	Not Applicable
polypeptide	ENSMUSP00000151439	Ensembl \| MGI Sequence Detail	1100	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007571 formin-like protein 1

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR014767 Diaphanous autoregulatory (DAD) domain

IPR015425 Formin, FH2 domain

IPR042201 Formin, FH2 domain superfamily

IPR010472 Formin, FH3 domain

IPR010473 Formin, GTPase-binding domain

IPR043592 Formin-like protein, animal

IPR014768 Rho GTPase-binding/formin homology 3 (GBD/FH3) domain

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All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 6

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MGI:1924425, MGI:2144223

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 11
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:357418 Sigler AL, et al., FMNL1 and mDia1 promote efficient T cell migration through complex environments via distinct mechanisms. Front Immunol. 2024;15:1467415

TSS for Fmnl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105316	Chr11:103061242-103061253 (+)	-685 bp
Tssr105317	Chr11:103061319-103061322 (+)	-612 bp
Tssr105318	Chr11:103061553-103061566 (+)	-373 bp
Tssr105319	Chr11:103061583-103061656 (+)	-313 bp
Tssr105320	Chr11:103061672-103061687 (+)	-253 bp
Tssr105321	Chr11:103061789-103061804 (+)	-136 bp
Tssr105322	Chr11:103061818-103061835 (+)	-106 bp
Tssr105323	Chr11:103061907-103061948 (+)	-5 bp
Tssr105324	Chr11:103072524-103072528 (+)	10,593 bp
Tssr105325	Chr11:103083223-103083261 (+)	21,309 bp
Tssr105326	Chr11:103083443-103083516 (+)	21,547 bp
Tssr105327	Chr11:103083520-103083530 (+)	21,592 bp
Tssr105328	Chr11:103083531-103083538 (+)	21,602 bp
Tssr105329	Chr11:103083898-103083910 (+)	21,971 bp
Tssr105330	Chr11:103083926-103083939 (+)	22,000 bp
Tssr105331	Chr11:103083957-103083968 (+)	22,030 bp
Tssr105332	Chr11:103084431-103084477 (+)	22,521 bp
Tssr105333	Chr11:103088476-103088487 (+)	26,549 bp
Tssr105334	Chr11:103088503-103088513 (+)	26,575 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24