Usp29 MGI Mouse Gene Detail - MGI:1888998 - ubiquitin specific peptidase 29

Symbol

Usp29
Name

ubiquitin specific peptidase 29
Synonyms

Ocat

Feature Type

protein coding gene
IDs

MGI:1888998
NCBI Gene: 57775
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:6733577-6970218 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 4.04 cM
Mapping Data

10 experiments

SNPs within 2kb

5334 from dbSNP Build 142
Strain Annotations

17
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888998	protein coding gene	Chr7:6733560-6970219 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031615	protein coding gene	Chr7:3828141-4076264 (+)
A/J	MGP_AJ_G0031589	protein coding gene	Chr7:3722741-3958278 (+)
AKR/J	MGP_AKRJ_G0031516	protein coding gene	Chr7:3966016-4210988 (+)
BALB/cJ	MGP_BALBcJ_G0031597	protein coding gene	Chr7:3829811-4061691 (+)
C3H/HeJ	MGP_C3HHeJ_G0031318	protein coding gene	Chr7:3806944-4043697 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032060	protein coding gene	Chr7:4037601-4295563 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0030680	protein coding gene	Chr7:3689681-3945219 (+)
CBA/J	MGP_CBAJ_G0031275	protein coding gene	Chr7:4186628-4433909 (+)
DBA/2J	MGP_DBA2J_G0031433	protein coding gene	Chr7:3757289-3995316 (+)
FVB/NJ	MGP_FVBNJ_G0031387	protein coding gene	Chr7:3728866-3970091 (+)
LP/J	MGP_LPJ_G0031519	protein coding gene	Chr7:3962091-4200748 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031426	protein coding gene	Chr7:4171455-4436854 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032089	protein coding gene	Chr7:3752720-3995671 (+)
PWK/PhJ	MGP_PWKPhJ_G0030407	protein coding gene	Chr7:3908223-4154365 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030234	protein coding gene	Chr7:3339889-3576185 (+)
WSB/EiJ	MGP_WSBEiJ_G0030774	protein coding gene	Chr7:3904661-4168029 (+)

Human Ortholog

USP29, ubiquitin specific peptidase 29

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

USP29, ubiquitin specific peptidase 29
Synonyms

HOM-TES-84/86
Links

HGNC:18563

NCBI Gene ID: 57663

neXtProt AC: NX_Q9HBJ7

UniProt: Q9HBJ7
Chr Location

19q13.43; chr19:57119087-57131926 (+) GRCh38

MGI Vertebrate Homology

Usp29 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: USP29
Gene Tree

Usp29

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (ENU)

3
Endonuclease-mediated

4
Gene trapped

22
Targeted

3
Genomic Mutations

1 involving Usp29
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

117 strains or lines available

Paternal inheritance of a KO allele results in decreased birth weight and changes in chromosome methylation. Fathers carrying a KO allele sire smaller litters.

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

32
cDNA Data

23
Literature Summary

9

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

90
RefSeq

31
UniProt

3
CCDS

CCDS20784.1

Ensembl

ENSMUSG00000051527 (Evidence)
NCBI Gene

57775

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051527	Ensembl Gene Model \| MGI Sequence Detail	236642	C57BL/6J	± kb
transcript	ENSMUST00000200535	Ensembl \| MGI Sequence Detail	7540	Not Applicable
polypeptide	ENSMUSP00000143769	Ensembl \| MGI Sequence Detail	869	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017167 ubiquitin carboxyl-terminal hydrolase 29

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR050185 Ubiquitin carboxyl-terminal hydrolase

IPR032069 Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain

IPR038093 Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain superfamily

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain

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All nucleic 33

Genomic 6

cDNA 23

Primer pair 4

Microarray probesets 5

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MGI:1861732

Summaries

All 56

Developmental Gene Expression 9

Gene Ontology 5

Phenotypes 16
Earliest

J:63606 Szeto IY, et al., Ocat, a paternally expressed gene closely linked and transcribed in the opposite direction to Peg3. Genomics. 2000 Jul 15;67(2):221-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Usp29:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64456	Chr7:6733686-6733715 (+)	124 bp
Tssr64457	Chr7:6737120-6737137 (+)	3,552 bp
Tssr2076	Chr7:6777843-6777844 (+)	44,267 bp
Tssr64458	Chr7:6816772-6816774 (+)	83,196 bp
Tssr64459	Chr7:6897247-6897250 (+)	163,672 bp
Tssr2077	Chr7:6955212-6955220 (+)	221,639 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24