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Atp2c1 Gene Detail
Summary
  • Symbol
    Atp2c1
  • Name
    ATPase, Ca++-sequestering
  • Synonyms
    1700121J11Rik, ATP2C1A, D930003G21Rik, MGC:58010, PMR1, SPCA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889008
    NCBI Gene: 235574
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:105288561-105398456 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 56.61 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3016 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889008
 protein coding gene Chr9:105280738-105404518 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035215
 protein coding gene Chr9:107138377-107263077 (-)
A/J MGP_AJ_G0035195
 protein coding gene Chr9:103265702-103386074 (-)
AKR/J MGP_AKRJ_G0035127
 protein coding gene Chr9:105854913-105983632 (-)
BALB/cJ MGP_BALBcJ_G0035188
 protein coding gene Chr9:102969569-103091188 (-)
C3H/HeJ MGP_C3HHeJ_G0034898
 protein coding gene Chr9:106254866-106382234 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035708
 protein coding gene Chr9:110096013-110231549 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032606
 protein coding gene Chr9:100793897-100917316 (-)
CAST/EiJ MGP_CASTEiJ_G0034210
 protein coding gene Chr9:106135415-106275485 (-)
CBA/J MGP_CBAJ_G0034867
 protein coding gene Chr9:113933825-114058871 (-)
DBA/2J MGP_DBA2J_G0035028
 protein coding gene Chr9:102751668-102872980 (-)
FVB/NJ MGP_FVBNJ_G0034976
 protein coding gene Chr9:101527635-101644310 (-)
LP/J MGP_LPJ_G0035104
 protein coding gene Chr9:107351761-107478306 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035015
 protein coding gene Chr9:115642094-115773329 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035730
 protein coding gene Chr9:106096345-106219349 (-)
PWK/PhJ MGP_PWKPhJ_G0033917
 protein coding gene Chr9:103039213-103164830 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033752
 protein coding gene Chr9:106155073-106282312 (-)
WSB/EiJ MGP_WSBEiJ_G0034330
 protein coding gene Chr9:105968176-106106473 (-)



Homology
more
  • Human Ortholog
    ATP2C1, ATPase secretory pathway Ca2+ transporting 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP2C1, ATPase secretory pathway Ca2+ transporting 1
  • Synonyms
    ATP2C1A, BCPM, HHD, hSPCA1, PMR1, SPCA1
  • Links
    NCBI Gene ID: 27032
    neXtProt AC: NX_P98194
    UniProt: P98194

  • Chr Location
    3q22.1; chr3:130850595-131016712 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ATP2C1 associations

Human Disease Mouse Models
      
IDs
 View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    4 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show embryonic growth retardation, failure of rostral neural tube closure, Golgi and endoplasmic reticulum stress, increased apoptosis, accumulation of intracellular lipid droplets and midgestational lethality. Aged heterozygotes develop squamous cell tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    9
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 235574 NCBI Gene Model | MGI Sequence Detail 109896 C57BL/6J ±  kb
    transcript NM_001359822 RefSeq | MGI Sequence Detail 4901 C57BL/6  
    polypeptide Q80XR2 UniProt | EBI | MGI Sequence Detail 918 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 15
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1923888, MGI:2143288, MGI:2444235
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:64183 Shull GE, Gene knockout studies of Ca2+-transporting ATPases. Eur J Biochem. 2000 Sep;267(17):5284-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory