Sncb MGI Mouse Gene Detail - MGI:1889011

Symbol

Sncb
Name

synuclein, beta
Synonyms

betaSYN

Feature Type

protein coding gene
IDs

MGI:1889011
NCBI Gene: 104069
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr13:54906673-54914408 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 29.28 cM
Mapping Data

3 experiments

SNPs within 2kb

235 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889011	protein coding gene	Chr13:54906673-54914435 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020579	protein coding gene	Chr13:54183659-54191789 (-)
A/J	MGP_AJ_G0020533	protein coding gene	Chr13:52184959-52192696 (-)
AKR/J	MGP_AKRJ_G0020511	protein coding gene	Chr13:53728410-53736148 (-)
BALB/cJ	MGP_BALBcJ_G0020529	protein coding gene	Chr13:52424114-52431850 (-)
C3H/HeJ	MGP_C3HHeJ_G0020328	protein coding gene	Chr13:53545909-53555669 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020963	protein coding gene	Chr13:55840179-55847899 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018545	protein coding gene	Chr13:50181658-50189400 (-)
CAST/EiJ	MGP_CASTEiJ_G0019842	protein coding gene	Chr13:53633429-53641504 (-)
CBA/J	MGP_CBAJ_G0020288	protein coding gene	Chr13:57961441-57969254 (-)
DBA/2J	MGP_DBA2J_G0020411	protein coding gene	Chr13:51753237-51761324 (-)
FVB/NJ	MGP_FVBNJ_G0020390	protein coding gene	Chr13:51213836-51224091 (-)
LP/J	MGP_LPJ_G0020487	protein coding gene	Chr13:54451048-54458816 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020420	protein coding gene	Chr13:57477815-57485552 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021006	protein coding gene	Chr13:53320035-53329275 (-)
PWK/PhJ	MGP_PWKPhJ_G0019598	protein coding gene	Chr13:51747888-51755539 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019425	protein coding gene	Chr13:52240745-52248519 (-)
WSB/EiJ	MGP_WSBEiJ_G0019904	protein coding gene	Chr13:53654419-53662156 (-)

Human Ortholog

SNCB, synuclein beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNCB, synuclein beta
Links

HGNC:11140

NCBI Gene ID: 6620

neXtProt AC: NX_Q16143

UniProt: Q16143
Chr Location

5q35.2; chr5:176620082-176630556 (-) GRCh38

MGI Vertebrate Homology

Sncb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNCB
Gene Tree

Sncb

Diseases

2 with human SNCB associations

				Human Disease	Mouse Models
				Lewy body dementia IDs Lewy body dementia DOID:12217 ICD10CM:G31.83 ICD9CM_2006:331.82 ICD9CM:331.82 MESH:D020961 NCI:C84826 OMIM:127750 UMLS_CUI:C0752347
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

9
Genomic Mutations

2 involving Sncb
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display an essentially normal phenotype.

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All GO Annotations

33
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

785
Tissues

54
cDNA Data

25
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SNCB

Xenbase sncb

ZFIN sncb

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All Sequences

38
RefSeq

6
UniProt

1
CCDS

CCDS36670.1

Ensembl

ENSMUSG00000034891 (Evidence)
NCBI Gene

104069

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034891	Ensembl Gene Model \| MGI Sequence Detail	7736	C57BL/6J	± kb
transcript	ENSMUST00000036825	Ensembl \| MGI Sequence Detail	1351	Not Applicable
polypeptide	ENSMUSP00000043074	Ensembl \| MGI Sequence Detail	133	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015324 beta-synuclein

(term hierarchy)
InterPro Domains

IPR002461 Beta-synuclein

IPR001058 Synuclein
GlyGen

Q91ZZ3 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 27

cDNA 26

Primer pair 1

Microarray probesets 3

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MGI:2138328

Summaries

All 77

Developmental Gene Expression 13

Diseases 1

Gene Ontology 11

Phenotypes 29
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sncb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122656	Chr13:54914366-54914385 (-)	32 bp
Tssr122655	Chr13:54914313-54914316 (-)	93 bp
Tssr122654	Chr13:54913661-54913720 (-)	717 bp
Tssr122653	Chr13:54913517-54913533 (-)	883 bp
Tssr122652	Chr13:54913442-54913461 (-)	956 bp
Tssr122651	Chr13:54913406-54913428 (-)	991 bp
Tssr122650	Chr13:54910761-54910784 (-)	3,635 bp
Tssr122649	Chr13:54910526-54910542 (-)	3,874 bp
Tssr122648	Chr13:54910508-54910522 (-)	3,893 bp
Tssr122647	Chr13:54907730-54907768 (-)	6,659 bp
Tssr122646	Chr13:54907320-54907331 (-)	7,082 bp
Tssr122645	Chr13:54907246-54907254 (-)	7,158 bp
Tssr122644	Chr13:54907187-54907216 (-)	7,206 bp
Tssr122643	Chr13:54907118-54907126 (-)	7,286 bp
Tssr122642	Chr13:54907021-54907031 (-)	7,382 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24