Cd200r1 MGI Mouse Gene Detail - MGI:1889024

Symbol

Cd200r1
Name

CD200 receptor 1
Synonyms

CD200R, Mox2r, OX2R

Feature Type

protein coding gene
IDs

MGI:1889024
NCBI Gene: 57781
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr16:44586141-44615341 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 29.08 cM, cytoband B5
Mapping Data

1 experiment

SNPs within 2kb

1023 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889024	protein coding gene	Chr16:44586099-44615341 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022843	protein coding gene	Chr16:43533277-43570046 (+)
A/J	MGP_AJ_G0022808	protein coding gene	Chr16:41586609-41617353 (+)
AKR/J	MGP_AKRJ_G0022780	protein coding gene	Chr16:42910232-42938231 (+)
BALB/cJ	MGP_BALBcJ_G0022809	protein coding gene	Chr16:41577599-41612001 (+)
C3H/HeJ	MGP_C3HHeJ_G0022573	protein coding gene	Chr16:43114003-43142878 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023256	protein coding gene	Chr16:44522048-44554727 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020771	protein coding gene	Chr16:41623812-41659186 (+)
CAST/EiJ	MGP_CASTEiJ_G0022099	protein coding gene	Chr16:43307351-43338989 (+)
CBA/J	MGP_CBAJ_G0022544	protein coding gene	Chr16:46409606-46450085 (+)
DBA/2J	MGP_DBA2J_G0022676	protein coding gene	Chr16:41321262-41352455 (+)
FVB/NJ	MGP_FVBNJ_G0022651	protein coding gene	Chr16:41274205-41304530 (+)
LP/J	MGP_LPJ_G0022744	protein coding gene	Chr16:43260548-43301108 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022670	protein coding gene	Chr16:45789857-45824697 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023271	protein coding gene	Chr16:42941568-42974465 (+)
PWK/PhJ	MGP_PWKPhJ_G0021839	protein coding gene	Chr16:41695345-41725319 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021670	protein coding gene	Chr16:42853635-42889634 (+)
WSB/EiJ	MGP_WSBEiJ_G0022143	protein coding gene	Chr16:43036696-43075033 (+)

Human Ortholog

CD200R1, CD200 receptor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD200R1, CD200 receptor 1
Synonyms

CD200R, HCRTR2, MOX2R, OX2R
Links

HGNC:24235

NCBI Gene ID: 131450

neXtProt AC: NX_Q8TD46

UniProt: Q8TD46
Chr Location

3q13.2; chr3:112921205-112975103 (-) GRCh38

Human Ortholog

CD200R1L, CD200 receptor 1 like
Synonyms

CD200R2, CD200RLa
Links

HGNC:24665

NCBI Gene ID: 344807

neXtProt AC: NX_Q6Q8B3

UniProt: Q6Q8B3
Chr Location

3q13.2; chr3:112815709-112846864 (-) GRCh38

MGI Vertebrate Homology

Cd200r1 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CD200R1, CD200R1L
Gene Tree

Cd200r1

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
2 images
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

6
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available

Mice homozygous for a disruption of this gene display abnormal sleep patterns including fragmented vigilance states and diminished duration of wakefulness. Mice homozygous for a different knock-out allele exhibit protection from HSV-1 encephalitis.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

773
Tissues

32
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cd200r1

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All Sequences

44
RefSeq

2
UniProt

3
CCDS

CCDS28189.1

Ensembl

ENSMUSG00000022667 (Evidence)
NCBI Gene

57781

			Length	Strain/Species	Flank
genomic	57781	NCBI Gene Model \| MGI Sequence Detail	29201	C57BL/6J	± kb
transcript	NM_021325	RefSeq \| MGI Sequence Detail	1850	C57BL/6
polypeptide	Q9ES57	UniProt \| EBI \| MGI Sequence Detail	326	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005161 cell surface glycoprotein CD200 receptor 1

(term hierarchy)
PDB

4BFG, 4BFI
InterPro Domains

IPR013162 CD80-like, immunoglobulin C2-set

IPR040012 Cell surface glycoprotein CD200 receptor

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain
GlyGen

Q9ES57 11 sites, 2 N-linked glycans (2 sites)

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All nucleic 12

cDNA 12

Microarray probesets 4

Summaries

All 67

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 20
Earliest

J:64171 Wright GJ, et al., Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity. 2000 Aug;13(2):233-42
Latest

J:349679 Pannunzio B, et al., CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury. Cells. 2022 May 30;11(11)

TSS for Cd200r1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138561	Chr16:44586095-44586114 (+)	-36 bp
Tssr138562	Chr16:44586116-44586191 (+)	13 bp
Tssr138563	Chr16:44586195-44586200 (+)	57 bp
Tssr138564	Chr16:44586261-44586283 (+)	131 bp
Tssr138565	Chr16:44586468-44586476 (+)	331 bp
Tssr138566	Chr16:44586530-44586543 (+)	396 bp
Tssr138567	Chr16:44592150-44592178 (+)	6,023 bp
Tssr138568	Chr16:44593642-44593653 (+)	7,507 bp
Tssr138569	Chr16:44594965-44594979 (+)	8,831 bp
Tssr138570	Chr16:44595502-44595533 (+)	9,377 bp
Tssr138571	Chr16:44599798-44599814 (+)	13,665 bp
Tssr138572	Chr16:44607041-44607058 (+)	20,909 bp
Tssr138573	Chr16:44607647-44607674 (+)	21,520 bp
Tssr138574	Chr16:44615153-44615170 (+)	29,021 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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