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Cks1b Gene Detail
Summary
  • Symbol
    Cks1b
  • Name
    CDC28 protein kinase 1b
  • Synonyms
    2410005G18Rik, 2610005D03Rik, Cks1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889208
    NCBI Gene: 54124
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89322779-89325598 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889208
 protein coding gene Chr3:89322779-89325690 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027438
 protein coding gene Chr3:89630146-89633015 (-)
A/J MGP_AJ_G0027402
 protein coding gene Chr3:86663555-86666488 (-)
AKR/J MGP_AKRJ_G0027366
 protein coding gene Chr3:88760300-88763280 (-)
BALB/cJ MGP_BALBcJ_G0027411
 protein coding gene Chr3:86630846-86633769 (-)
C3H/HeJ MGP_C3HHeJ_G0027153
 protein coding gene Chr3:88963922-88966860 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027857
 protein coding gene Chr3:93016274-93019181 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025209
 protein coding gene Chr3:82145898-82149171 (-)
CAST/EiJ MGP_CASTEiJ_G0026599
 protein coding gene Chr3:89320316-89323227 (-)
CBA/J MGP_CBAJ_G0027127
 protein coding gene Chr3:96205937-96208854 (-)
DBA/2J MGP_DBA2J_G0027265
 protein coding gene Chr3:86041270-86044230 (-)
FVB/NJ MGP_FVBNJ_G0027233
 protein coding gene Chr3:84384150-84387089 (-)
LP/J MGP_LPJ_G0027374
 protein coding gene Chr3:90709538-90712429 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027253
 protein coding gene Chr3:102415770-102418651 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027916
 protein coding gene Chr3:88515683-88519445 (-)
PWK/PhJ MGP_PWKPhJ_G0026333
 protein coding gene Chr3:85919178-85922469 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026152
 protein coding gene Chr3:87689622-87692919 (-)
WSB/EiJ MGP_WSBEiJ_G0026681
 protein coding gene Chr3:88909204-88912101 (-)



Homology
more
  • Human Ortholog
    CKS1B, CDC28 protein kinase regulatory subunit 1B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CKS1B, CDC28 protein kinase regulatory subunit 1B
  • Synonyms
    CKS1, ckshs1, PNAS-16, PNAS-18
  • Links
    NCBI Gene ID: 1163
    neXtProt AC: NX_P61024
    UniProt: P61024

  • Chr Location
    1q21.3; chr1:154974653-154979251 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele exhibit a reduced body size that persists through adulthood while heterozygous mice are intermediate in size. Mutant mouse embryonic fibroblasts (MEFs) proliferate poorly and senesce earlier than wild-type MEFs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    13
  • cDNA Data
    123
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54124 NCBI Gene Model | MGI Sequence Detail 2820 C57BL/6J ±  kb
    transcript NM_016904 RefSeq | MGI Sequence Detail 757 Not Specified  
    polypeptide P61025 UniProt | EBI | MGI Sequence Detail 79 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005518 cyclin-dependent kinases regulatory subunit 1
      (term hierarchy)
    • InterPro Domains
      IPR000789 Cyclin-dependent kinase, regulatory subunit
      IPR036858 Cyclin-dependent kinase, regulatory subunit superfamily
    Molecular
    Reagents
    less
    • All nucleic 125
      cDNA 124
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1913740, MGI:1914364, MGI:2139555
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 4
      Phenotypes 23
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:332515 Wan L, et al., Disruption of Cdyl gene impairs mouse lung epithelium differentiation and maturation. Gene. 2023 Feb 15;853:147088
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory