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Astn2 Gene Detail
Summary
  • Symbol
    Astn2
  • Name
    astrotactin 2
  • Synonyms
    1d8, Astnl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889277
    NCBI Gene: 56079
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:65299040-66322774 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 34.31 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26677 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889277
 protein coding gene Chr4:65299040-66322848 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028377
 protein coding gene Chr4:64456113-65507466 (-)
A/J MGP_AJ_G0028338
 protein coding gene Chr4:62150350-63178141 (-)
AKR/J MGP_AKRJ_G0028287
 protein coding gene Chr4:63821605-64836201 (-)
BALB/cJ MGP_BALBcJ_G0028358
 protein coding gene Chr4:62351465-63360761 (-)
C3H/HeJ MGP_C3HHeJ_G0028073
 protein coding gene Chr4:64372945-65436441 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028798
 protein coding gene Chr4:66661778-67754783 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026101
 protein coding gene Chr4:59374889-60330840 (-)
CAST/EiJ MGP_CASTEiJ_G0027514
 protein coding gene Chr4:62368116-63380357 (-)
CBA/J MGP_CBAJ_G0028042
 protein coding gene Chr4:68995879-70078801 (-)
DBA/2J MGP_DBA2J_G0028191
 protein coding gene Chr4:61978894-62984500 (-)
FVB/NJ MGP_FVBNJ_G0028157
 protein coding gene Chr4:61225655-62212549 (-)
LP/J MGP_LPJ_G0028290
 protein coding gene Chr4:64734543-65783711 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028186
 protein coding gene Chr4:72153105-73252689 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028834
 protein coding gene Chr4:63959104-64990702 (-)
PWK/PhJ MGP_PWKPhJ_G0027241
 protein coding gene Chr4:60544811-61523604 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027067
 protein coding gene Chr4:61462132-62491537 (-)
WSB/EiJ MGP_WSBEiJ_G0027591
 protein coding gene Chr4:64010865-65057891 (-)



Homology
more
  • Human Ortholog
    ASTN2, astrotactin 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASTN2, astrotactin 2
  • Synonyms
    bA67K19.1
  • Links
    NCBI Gene ID: 23245
    neXtProt AC: NX_O75129
    UniProt: O75129

  • Chr Location
    9q33.1; chr9:116423112-117415070 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1019
  • Tissues
    78
  • cDNA Data
    7
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56079 NCBI Gene Model | MGI Sequence Detail 1023735 C57BL/6J ±  kb
transcript NM_207109 RefSeq | MGI Sequence Detail 4831 C57BL/6  
polypeptide Q80Z10 UniProt | EBI | MGI Sequence Detail 1352 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 12
    cDNA 10
    Primer pair 4

    Microarray probesets 2
Other
Accession IDs
less
MGI:1341896
References
more
  • Summaries
    All 41
    Developmental Gene Expression 11
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:53343 Qureshi ST, et al., Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments]. J Exp Med. 1999 Feb 15;189(4):615-25
  • Latest
    J:359224 Hanzel M, et al., Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties. Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2405901121
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory