Cbln3 MGI Mouse Gene Detail - MGI:1889286 - cerebellin 3 precursor protein

Symbol

Cbln3
Name

cerebellin 3 precursor protein

Feature Type

protein coding gene
IDs

MGI:1889286
NCBI Gene: 56410
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr14:56116377-56121713 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM
Mapping Data

1 experiment

SNPs within 2kb

192 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889286	protein coding gene	Chr14:56116370-56121849 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021375	protein coding gene	Chr14:49937162-49942498 (-)
A/J	MGP_AJ_G0021334	protein coding gene	Chr14:48927329-48932665 (-)
AKR/J	MGP_AKRJ_G0021310	protein coding gene	Chr14:50694089-50700763 (-)
BALB/cJ	MGP_BALBcJ_G0021338	protein coding gene	Chr14:48901231-48906567 (-)
C3H/HeJ	MGP_C3HHeJ_G0021118	protein coding gene	Chr14:50378194-50383530 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021776	protein coding gene	Chr14:52438241-52443577 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019323	protein coding gene	Chr14:47290405-47295878 (-)
CAST/EiJ	MGP_CASTEiJ_G0020637	protein coding gene	Chr14:46628400-46642722 (-)
CBA/J	MGP_CBAJ_G0021085	protein coding gene	Chr14:54001138-54006474 (-)
DBA/2J	MGP_DBA2J_G0021206	protein coding gene	Chr14:48647376-48653040 (-)
FVB/NJ	MGP_FVBNJ_G0021188	protein coding gene	Chr14:48096462-48101800 (-)
LP/J	MGP_LPJ_G0021280	protein coding gene	Chr14:50975728-50981064 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021212	protein coding gene	Chr14:53351801-53357141 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021803	protein coding gene	Chr14:49868227-49873563 (-)
PWK/PhJ	MGP_PWKPhJ_G0020384	protein coding gene	Chr14:45184824-45190203 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020212	protein coding gene	Chr14:45860041-45865386 (-)
WSB/EiJ	MGP_WSBEiJ_G0020690	protein coding gene	Chr14:50148727-50154064 (-)

Human Ortholog

CBLN3, cerebellin 3 precursor

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CBLN3, cerebellin 3 precursor
Synonyms

PRO1486
Links

HGNC:20146

NCBI Gene ID: 643866

neXtProt AC: NX_Q6UW01

UniProt: Q6UW01
Chr Location

14q12

MGI Vertebrate Homology

Cbln3 stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: CBLN3
Gene Tree

Cbln3

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Cbln3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available

Mice homozygous for a knock-out allele are viable, fertile and behaviorally normal with no apparent defects in cerebellar foliation and lamination or Purkinje cell morphology.

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

876
Tissues

74
cDNA Data

10
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS27133.1

Ensembl

ENSMUSG00000040380 (Evidence)
NCBI Gene

56410

			Length	Strain/Species	Flank
genomic	56410	NCBI Gene Model \| MGI Sequence Detail	5337	C57BL/6J	± kb
transcript	NM_019820	RefSeq \| MGI Sequence Detail	4723	ZRU/MplStud
polypeptide	Q9JHG0	UniProt \| EBI \| MGI Sequence Detail	197	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005076 cerebellin-3

(term hierarchy)
InterPro Domains

IPR001073 C1q domain

IPR050822 Cerebellin Synaptic Organizer

IPR008983 Tumour necrosis factor-like domain superfamily
GlyGen

Q9JHG0 1 site, 1 N-linked glycan (1 site)

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All nucleic 14

cDNA 10

Primer pair 3

Other 1

Microarray probesets 4

Summaries

All 37

Developmental Gene Expression 7

Gene Ontology 5

Phenotypes 13
Earliest

J:64199 Pang Z, et al., Cbln3, a novel member of the precerebellin family that binds specifically to cbln1. J Neurosci. 2000 Sep 1;20(17):6333-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cbln3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128907	Chr14:56123454-56123466 (-)	-1,747 bp
Tssr128906	Chr14:56123435-56123444 (-)	-1,727 bp
Tssr128905	Chr14:56121824-56121833 (-)	-116 bp
Tssr128904	Chr14:56121736-56121768 (-)	-39 bp
Tssr128903	Chr14:56121707-56121712 (-)	3 bp
Tssr128902	Chr14:56121680-56121694 (-)	26 bp
Tssr128901	Chr14:56121654-56121673 (-)	49 bp
Tssr128900	Chr14:56120327-56120359 (-)	1,370 bp
Tssr128899	Chr14:56120231-56120241 (-)	1,477 bp
Tssr128898	Chr14:56120205-56120220 (-)	1,500 bp
Tssr128897	Chr14:56120126-56120171 (-)	1,564 bp
Tssr128896	Chr14:56119650-56119653 (-)	2,061 bp
Tssr128895	Chr14:56119524-56119538 (-)	2,182 bp
Tssr128894	Chr14:56119507-56119508 (-)	2,205 bp
Tssr128893	Chr14:56119435-56119451 (-)	2,270 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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