Crlf2 MGI Mouse Gene Detail - MGI:1889506 - cytokine receptor-like factor 2

Symbol

Crlf2
Name

cytokine receptor-like factor 2
Synonyms

Ly114, Tpte2, Tslpr

Feature Type

protein coding gene
IDs

MGI:1889506
NCBI Gene: 57914
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:109702575-109706859 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 53.24 cM
Mapping Data

1 experiment

SNPs within 2kb

252 from dbSNP Build 142
Strain Annotations

17
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889506	protein coding gene	Chr5:109702575-109707301 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029874	protein coding gene	Chr5:111872909-111880211 (-)
A/J	MGP_AJ_G0029839	protein coding gene	Chr5:107534832-107539095 (-)
AKR/J	MGP_AKRJ_G0029779	protein coding gene	Chr5:110933845-110938098 (-)
BALB/cJ	MGP_BALBcJ_G0029851	protein coding gene	Chr5:108753282-108757845 (-)
C3H/HeJ	MGP_C3HHeJ_G0029572	protein coding gene	Chr5:111403507-111408466 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030302	protein coding gene	Chr5:116319503-116323834 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0028980	protein coding gene	Chr5:110249512-110289778 (-)
CBA/J	MGP_CBAJ_G0029539	protein coding gene	Chr5:120450052-120457075 (-)
DBA/2J	MGP_DBA2J_G0029688	protein coding gene	Chr5:107599397-107603597 (-)
FVB/NJ	MGP_FVBNJ_G0029645	protein coding gene	Chr5:106336045-106341129 (-)
LP/J	MGP_LPJ_G0029775	protein coding gene	Chr5:112384800-112388949 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029674	protein coding gene	Chr5:125216964-125221028 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030341	protein coding gene	Chr5:110427389-110431532 (-)
PWK/PhJ	MGP_PWKPhJ_G0028694	protein coding gene	Chr5:106273904-106281939 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028531	protein coding gene	Chr5:108000636-108004885 (-)
WSB/EiJ	MGP_WSBEiJ_G0029055	protein coding gene	Chr5:110885252-110889882 (-)

Human Ortholog

CRLF2, cytokine receptor like factor 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRLF2, cytokine receptor like factor 2
Synonyms

CRL2, CRLF2Y, TSLPR
Links

HGNC:14281

NCBI Gene ID: 64109

neXtProt AC: NX_Q9HC73

UniProt: Q9HC73
Chr Location

XY;Y

MGI Vertebrate Homology

Crlf2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CRLF2
Gene Tree

Crlf2

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Phenotype Summary

30 phenotypes from 3 alleles in 6 genetic backgrounds
4 phenotypes from multigenic genotypes
120 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Crlf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are overtly normal and maintain normal lymphopoiesis.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

16
cDNA Data

39
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN crlf2

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All Sequences

53
RefSeq

13
UniProt

6
CCDS

CCDS19521.1, CCDS80356.1

Ensembl

ENSMUSG00000033467 (Evidence)
NCBI Gene

57914

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033467	Ensembl Gene Model \| MGI Sequence Detail	4285	C57BL/6J	± kb
transcript	ENSMUST00000044579	Ensembl \| MGI Sequence Detail	1323	Not Applicable
polypeptide	ENSMUSP00000036326	Ensembl \| MGI Sequence Detail	359	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005886 cytokine receptor-like factor 2

(term hierarchy)
PDB

4NN5, 4NN6, 4NN7
InterPro Domains

IPR048648 Cytokine receptor-like factor 2-like, D2 domain

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold
GlyGen

Q8CII9 2 sites

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All nucleic 39

cDNA 39

Microarray probesets 3

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MGI:1355298

Summaries

All 158

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 120
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345793 Malinczak CA, et al., Early-life pulmonary viral infection leads to long-term functional and lower airway structural changes in the lungs. Am J Physiol Lung Cell Mol Physiol. 2024 Mar 1;326(3):L280-L291

TSS for Crlf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52476	Chr5:109706823-109706880 (-)	7 bp
Tssr52475	Chr5:109706811-109706822 (-)	42 bp
Tssr1582	Chr5:109706773-109706788 (-)	78 bp
Tssr52474	Chr5:109705665-109705671 (-)	1,191 bp
Tssr52473	Chr5:109704396-109704419 (-)	2,451 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24