Gsdma MGI Mouse Gene Detail - MGI:1889509

Symbol

Gsdma
Name

gasdermin A
Synonyms

Gsdm, Gsdm1, Gsdma1, H312E

Feature Type

protein coding gene
IDs

MGI:1889509
NCBI Gene: 57911
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:98555177-98568534 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 62.34 cM
Mapping Data

3 experiments

SNPs within 2kb

593 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889509	protein coding gene	Chr11:98555163-98568534 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019067	protein coding gene	Chr11:101255996-101269270 (+)
A/J	MGP_AJ_G0019035	protein coding gene	Chr11:97019891-97033665 (+)
AKR/J	MGP_AKRJ_G0019005	protein coding gene	Chr11:100027986-100041974 (+)
BALB/cJ	MGP_BALBcJ_G0019009	protein coding gene	Chr11:97512413-97528701 (+)
C3H/HeJ	MGP_C3HHeJ_G0018822	protein coding gene	Chr11:100157576-100183703 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019460	protein coding gene	Chr11:104342255-104355533 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017092	protein coding gene	Chr11:94577025-94590089 (+)
CAST/EiJ	MGP_CASTEiJ_G0018376	protein coding gene	Chr11:101146034-101165926 (+)
CBA/J	MGP_CBAJ_G0018793	protein coding gene	Chr11:108694975-108720605 (+)
DBA/2J	MGP_DBA2J_G0018901	protein coding gene	Chr11:96579650-96592910 (+)
FVB/NJ	MGP_FVBNJ_G0018890	protein coding gene	Chr11:96079118-96100009 (+)
LP/J	MGP_LPJ_G0018971	protein coding gene	Chr11:101716426-101730654 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018917	protein coding gene	Chr11:108418434-108435630 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019500	protein coding gene	Chr11:100367300-100383127 (+)
PWK/PhJ	MGP_PWKPhJ_G0018147	protein coding gene	Chr11:97599902-97620248 (+)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0018425	protein coding gene	Chr11:100320870-100334469 (+)

Human Ortholog

GSDMA, gasdermin A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GSDMA, gasdermin A
Synonyms

FKSG9, GSDM, GSDM1
Links

HGNC:13311

NCBI Gene ID: 284110

neXtProt AC: NX_Q96QA5

UniProt: Q96QA5
Chr Location

17q21.1; chr17:39953263-39977768 (+) GRCh38

MGI Vertebrate Homology

Gsdma stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GSDMA
Gene Tree

Gsdma

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

9
Gene trapped

1
Targeted

2
Genomic Mutations

3 involving Gsdma
Find Mice (IMSR)

24 strains or lines available

Mice homozygous for a null allele exhibit increased susceptibility to bacterial infection with a lack of pyroptosis.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

20
cDNA Data

25
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

4
UniProt

1
CCDS

CCDS25358.1

Ensembl

ENSMUSG00000017204 (Evidence)
NCBI Gene

57911

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017204	Ensembl Gene Model \| MGI Sequence Detail	13358	C57BL/6J	± kb
transcript	ENSMUST00000017348	Ensembl \| MGI Sequence Detail	2726	Not Applicable
polypeptide	ENSMUSP00000017348	Ensembl \| MGI Sequence Detail	446	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008280 gasdermin-A

(term hierarchy)
InterPro Domains

IPR040460 Gasdermin, pore forming domain

IPR041263 Gasdermin, PUB domain

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All nucleic 28

Genomic 1

cDNA 26

Primer pair 1

Microarray probesets 4

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MGI:2144607

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 14
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:349394 Fattinger SA, et al., Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2315503120

TSS for Gsdma:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104757	Chr11:98555167-98555182 (+)	-2 bp
Tssr104758	Chr11:98555186-98555199 (+)	16 bp
Tssr104759	Chr11:98555217-98555226 (+)	45 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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