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Adar Gene Detail
Summary
  • Symbol
    Adar
  • Name
    adenosine deaminase, RNA-specific
  • Synonyms
    ADAR1, Adar1p110, Adar1p150, mZaADAR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889575
    NCBI Gene: 56417
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89622329-89660753 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.19 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    899 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889575
 protein coding gene Chr3:89622321-89660756 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027444
 protein coding gene Chr3:89947630-89985000 (+)
A/J MGP_AJ_G0027408
 protein coding gene Chr3:86969673-87006912 (+)
AKR/J MGP_AKRJ_G0027372
 protein coding gene Chr3:89085089-89121358 (+)
BALB/cJ MGP_BALBcJ_G0027417
 protein coding gene Chr3:86942080-86978589 (+)
C3H/HeJ MGP_C3HHeJ_G0027159
 protein coding gene Chr3:89275622-89316019 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027863
 protein coding gene Chr3:93334986-93371286 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025215
 protein coding gene Chr3:82457954-82497211 (+)
CAST/EiJ MGP_CASTEiJ_G0026605
 protein coding gene Chr3:89653644-89691709 (+)
CBA/J MGP_CBAJ_G0027133
 protein coding gene Chr3:96551761-96592743 (+)
DBA/2J MGP_DBA2J_G0027271
 protein coding gene Chr3:86348917-86385764 (+)
FVB/NJ MGP_FVBNJ_G0027239
 protein coding gene Chr3:84683817-84720786 (+)
LP/J MGP_LPJ_G0027380
 protein coding gene Chr3:91020153-91057374 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027259
 protein coding gene Chr3:102736084-102773647 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027922
 protein coding gene Chr3:88831471-88869084 (+)
PWK/PhJ MGP_PWKPhJ_G0026339
 protein coding gene Chr3:86232892-86270800 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026158
 protein coding gene Chr3:88018639-88058872 (+)
WSB/EiJ MGP_WSBEiJ_G0026687
 protein coding gene Chr3:89232487-89272705 (+)



Homology
more
  • Human Ortholog
    ADAR, adenosine deaminase RNA specific
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAR, adenosine deaminase RNA specific
  • Synonyms
    ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI-4, IFI4, K88DSRBP, P136
  • Links
    NCBI Gene ID: 103
    neXtProt AC: NX_P55265
    UniProt: P55265

  • Chr Location
    1q21.3; chr1:154581695-154628013 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Adar mouse models; 4 with human ADAR associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 11 alleles in 12 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 images
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die during gestation. Inactivation of this locus has been associated with increased apoptosis and, in some lines, defects in both primitive and definitive hematopoiesis. Compound heterozygosity for the p.P195A mutation and KO affects liver, kidney and spleen, leading to low weight and severely shortening survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1011
  • Tissues
    212
  • cDNA Data
    161
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027951 Ensembl Gene Model | MGI Sequence Detail 38425 C57BL/6J ±  kb
    transcript ENSMUST00000107405 Ensembl | MGI Sequence Detail 5871 Not Applicable  
    polypeptide ENSMUSP00000103028 Ensembl | MGI Sequence Detail 1178 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000003745 double-stranded RNA-specific adenosine deaminase
      (term hierarchy)
    • EC
      3.5.4.37
    • InterPro Domains
      IPR044456 ADAR1, first double-stranded RNA binding domain
      IPR044457 ADAR1, third double-stranded RNA binding domain
      IPR002466 Adenosine deaminase/editase
      IPR014720 Double-stranded RNA-binding domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
      IPR042371 Z-binding domain
    • GlyGen
      Q99MU3 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 168
      Genomic 1
      cDNA 162
      Primer pair 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139942
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 20
      Diseases 3
      Gene Ontology 25
      Phenotypes 76
    • Earliest
      J:64308 Weier HU, et al., Assignment of the RNA-specific adenosine deaminase gene (Adar) to mouse chromosome 3F2 by in situ hybridization. Cytogenet Cell Genet. 2000;89(3-4):214-5
    • Latest
      J:353376 Cai D, et al., ADAR1 Is Essential for Smooth Muscle Homeostasis and Vascular Integrity. Cells. 2024 Jul 26;13(15)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory