Ppp1r1a MGI Mouse Gene Detail - MGI:1889595 - protein phosphatase 1, regulatory inhibitor subunit 1A

Symbol

Ppp1r1a
Name

protein phosphatase 1, regulatory inhibitor subunit 1A
Synonyms

0610038N18Rik, I-1, inhibitor-1, protein phosphatase inhibitor-1

Feature Type

protein coding gene
IDs

MGI:1889595
NCBI Gene: 58200
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:103438706-103446430 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 59.01 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

162 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889595	protein coding gene	Chr15:103438706-103446465 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022445	protein coding gene	Chr15:105800578-105811131 (-)
A/J	MGP_AJ_G0022407	protein coding gene	Chr15:101609620-101617256 (-)
AKR/J	MGP_AKRJ_G0022382	protein coding gene	Chr15:104696157-104703887 (-)
BALB/cJ	MGP_BALBcJ_G0022411	protein coding gene	Chr15:101658413-101666818 (-)
C3H/HeJ	MGP_C3HHeJ_G0022178	protein coding gene	Chr15:104800439-104808092 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022860	protein coding gene	Chr15:109709057-109716708 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020383	protein coding gene	Chr15:97371446-97379064 (-)
CAST/EiJ	MGP_CASTEiJ_G0021704	protein coding gene	Chr15:105658342-105665874 (-)
CBA/J	MGP_CBAJ_G0022147	protein coding gene	Chr15:113548998-113558129 (-)
DBA/2J	MGP_DBA2J_G0022278	protein coding gene	Chr15:100888375-100895890 (-)
FVB/NJ	MGP_FVBNJ_G0022254	protein coding gene	Chr15:99941100-99948615 (-)
LP/J	MGP_LPJ_G0022347	protein coding gene	Chr15:105947664-105955334 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022276	protein coding gene	Chr15:117037685-117045193 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022872	protein coding gene	Chr15:104728388-104736041 (-)
PWK/PhJ	MGP_PWKPhJ_G0021444	protein coding gene	Chr15:101075183-101082751 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021276	protein coding gene	Chr15:104571003-104578514 (-)
WSB/EiJ	MGP_WSBEiJ_G0021754	protein coding gene	Chr15:105352452-105360104 (-)

Human Ortholog

PPP1R1A, protein phosphatase 1 regulatory inhibitor subunit 1A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP1R1A, protein phosphatase 1 regulatory inhibitor subunit 1A
Synonyms

I1, IPP1
Links

HGNC:9286

NCBI Gene ID: 5502

neXtProt AC: NX_Q13522

UniProt: Q13522
Chr Location

12q13.2; chr12:54575387-54588659 (-) GRCh38

MGI Vertebrate Homology

Ppp1r1a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PPP1R1A
Gene Tree

Ppp1r1a

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

Homozygous mutant mice show decreased long term poteniation, but normal performance in water maze tests.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

954
Tissues

106
cDNA Data

36
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp1r1a

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All Sequences

35
RefSeq

3
UniProt

2
CCDS

CCDS37237.1

Ensembl

ENSMUSG00000022490 (Evidence)
NCBI Gene

58200

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022490	Ensembl Gene Model \| MGI Sequence Detail	7725	C57BL/6J	± kb
transcript	ENSMUST00000023133	Ensembl \| MGI Sequence Detail	1306	Not Applicable
polypeptide	ENSMUSP00000023133	Ensembl \| MGI Sequence Detail	171	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013120 protein phosphatase 1 regulatory subunit 1A

(term hierarchy)
InterPro Domains

IPR008466 Protein phosphatase inhibitor 1
GlyGen

Q9ERT9 1 site, 1 O-linked glycan (1 site)

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All nucleic 37

Genomic 1

cDNA 36

Microarray probesets 3

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MGI:1915628

Summaries

All 48

Developmental Gene Expression 9

Gene Ontology 5

Phenotypes 15
Earliest

J:62800 Svenningsson P, et al., Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32. J Neurochem. 2000 Jul;75(1):248-57
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Ppp1r1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136797	Chr15:103446737-103446768 (-)	-323 bp
Tssr136796	Chr15:103446448-103446459 (-)	-24 bp
Tssr136795	Chr15:103446355-103446446 (-)	29 bp
Tssr136794	Chr15:103442819-103442831 (-)	3,605 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24