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Ppp1r1a Gene Detail
Summary
  • Symbol
    Ppp1r1a
  • Name
    protein phosphatase 1, regulatory inhibitor subunit 1A
  • Synonyms
    0610038N18Rik, I-1, inhibitor-1, protein phosphatase inhibitor-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889595
    NCBI Gene: 58200
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:103438706-103446430 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 59.01 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    162 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889595
 protein coding gene Chr15:103438706-103446465 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022445
 protein coding gene Chr15:105800578-105811131 (-)
A/J MGP_AJ_G0022407
 protein coding gene Chr15:101609620-101617256 (-)
AKR/J MGP_AKRJ_G0022382
 protein coding gene Chr15:104696157-104703887 (-)
BALB/cJ MGP_BALBcJ_G0022411
 protein coding gene Chr15:101658413-101666818 (-)
C3H/HeJ MGP_C3HHeJ_G0022178
 protein coding gene Chr15:104800439-104808092 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022860
 protein coding gene Chr15:109709057-109716708 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020383
 protein coding gene Chr15:97371446-97379064 (-)
CAST/EiJ MGP_CASTEiJ_G0021704
 protein coding gene Chr15:105658342-105665874 (-)
CBA/J MGP_CBAJ_G0022147
 protein coding gene Chr15:113548998-113558129 (-)
DBA/2J MGP_DBA2J_G0022278
 protein coding gene Chr15:100888375-100895890 (-)
FVB/NJ MGP_FVBNJ_G0022254
 protein coding gene Chr15:99941100-99948615 (-)
LP/J MGP_LPJ_G0022347
 protein coding gene Chr15:105947664-105955334 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022276
 protein coding gene Chr15:117037685-117045193 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022872
 protein coding gene Chr15:104728388-104736041 (-)
PWK/PhJ MGP_PWKPhJ_G0021444
 protein coding gene Chr15:101075183-101082751 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021276
 protein coding gene Chr15:104571003-104578514 (-)
WSB/EiJ MGP_WSBEiJ_G0021754
 protein coding gene Chr15:105352452-105360104 (-)



Homology
more
  • Human Ortholog
    PPP1R1A, protein phosphatase 1 regulatory inhibitor subunit 1A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R1A, protein phosphatase 1 regulatory inhibitor subunit 1A
  • Synonyms
    I1, IPP1
  • Links
    NCBI Gene ID: 5502
    neXtProt AC: NX_Q13522
    UniProt: Q13522

  • Chr Location
    12q13.2; chr12:54575387-54588659 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice show decreased long term poteniation, but normal performance in water maze tests.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    954
  • Tissues
    106
  • cDNA Data
    36
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022490 Ensembl Gene Model | MGI Sequence Detail 7725 C57BL/6J ±  kb
transcript ENSMUST00000023133 Ensembl | MGI Sequence Detail 1306 Not Applicable  
polypeptide ENSMUSP00000023133 Ensembl | MGI Sequence Detail 171 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013120 protein phosphatase 1 regulatory subunit 1A
    (term hierarchy)
  • InterPro Domains
    IPR008466 Protein phosphatase inhibitor 1
  • GlyGen
    Q9ERT9 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 37
    Genomic 1
    cDNA 36

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915628
References
more
  • Summaries
    All 48
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:62800 Svenningsson P, et al., Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32. J Neurochem. 2000 Jul;75(1):248-57
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory