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Fam13a Gene Detail
Summary
  • Symbol
    Fam13a
  • Name
    family with sequence similarity 13, member A
  • Synonyms
    D430015B01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889842
    NCBI Gene: 58909
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:58910521-59001487 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 27.93 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2240 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889842
 protein coding gene Chr6:58909075-59001534 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030820
 protein coding gene Chr6:58564256-58664878 (-)
A/J MGP_AJ_G0030787
 protein coding gene Chr6:56032844-56122040 (-)
AKR/J MGP_AKRJ_G0030715
 protein coding gene Chr6:57874037-57970696 (-)
BALB/cJ MGP_BALBcJ_G0030799
 protein coding gene Chr6:56323153-56412936 (-)
C3H/HeJ MGP_C3HHeJ_G0030513
 protein coding gene Chr6:57853069-57944777 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031257
 protein coding gene Chr6:59851562-59945854 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028449
 protein coding gene Chr6:53042897-53132515 (-)
CAST/EiJ MGP_CASTEiJ_G0029911
 protein coding gene Chr6:57511712-57610152 (-)
CBA/J MGP_CBAJ_G0030486
 protein coding gene Chr6:62354102-62443233 (-)
DBA/2J MGP_DBA2J_G0030637
 protein coding gene Chr6:55739861-55830571 (-)
FVB/NJ MGP_FVBNJ_G0030590
 protein coding gene Chr6:55283566-55376867 (-)
LP/J MGP_LPJ_G0030722
 protein coding gene Chr6:58491725-58584384 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030625
 protein coding gene Chr6:65009044-65102356 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031283
 protein coding gene Chr6:57738295-57829908 (-)
PWK/PhJ MGP_PWKPhJ_G0029626
 protein coding gene Chr6:55487263-55579562 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029453
 protein coding gene Chr6:56943110-57034659 (-)
WSB/EiJ MGP_WSBEiJ_G0029992
 protein coding gene Chr6:57930870-58022198 (-)



Homology
more
  • Human Ortholog
    FAM13A, family with sequence similarity 13 member A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM13A, family with sequence similarity 13 member A
  • Synonyms
    ARHGAP48, FAM13A1
  • Links
    NCBI Gene ID: 10144
    neXtProt AC: NX_O94988
    UniProt: O94988

  • Chr Location
    4q22.1; chr4:88725955-89111398 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FAM13A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele are resistant to cigarette-induced emphysema. Homozygotes for a different null allele show impaired insulin signaling in WAT and enhanced lipolysis leading to exacerbated WAT inflammation, high FFA levels, glucose intolerance and insulin resistance under high-fat diet.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    59
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58909 NCBI Gene Model | MGI Sequence Detail 90967 C57BL/6J ±  kb
    transcript NM_153574 RefSeq | MGI Sequence Detail 4300 C57BL/6  
    polypeptide Q8BGI4 UniProt | EBI | MGI Sequence Detail 693 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 59

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Phenotypes 17
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory