About   Help   FAQ
Slc6a14 Gene Detail
Summary
  • Symbol
    Slc6a14
  • Name
    solute carrier family 6 (neurotransmitter transporter), member 14
  • Synonyms
    1110007A17Rik, 9030613J17Rik, ATB0plus, CATB0plus
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890216
    NCBI Gene: 56774
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:21581139-21608597 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 16.78 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    403 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890216
 protein coding gene ChrX:21581135-21608597 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035609
 protein coding gene ChrX:16632298-16662329 (+)
A/J MGP_AJ_G0035586
 protein coding gene ChrX:16727962-16755219 (+)
AKR/J MGP_AKRJ_G0035519
 protein coding gene ChrX:17319918-17351275 (+)
BALB/cJ MGP_BALBcJ_G0035579
 protein coding gene ChrX:16473925-16501553 (+)
C3H/HeJ MGP_C3HHeJ_G0035297
 protein coding gene ChrX:16855848-16883815 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036115
 protein coding gene ChrX:17116320-17146704 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032979
 protein coding gene ChrX:15008159-15035773 (+)
CAST/EiJ MGP_CASTEiJ_G0034588
 protein coding gene ChrX:16149721-16178499 (+)
CBA/J MGP_CBAJ_G0035266
 protein coding gene ChrX:17874522-17901798 (+)
DBA/2J MGP_DBA2J_G0035418
 protein coding gene ChrX:16538976-16566366 (+)
FVB/NJ MGP_FVBNJ_G0035364
 protein coding gene ChrX:16419213-16449517 (+)
LP/J MGP_LPJ_G0035500
 protein coding gene ChrX:16907367-16934670 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035408
 protein coding gene ChrX:18159773-18207359 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036122
 protein coding gene ChrX:16573363-16603238 (+)
PWK/PhJ MGP_PWKPhJ_G0034289
 protein coding gene ChrX:15685146-15713741 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034129
 protein coding gene ChrX:16576567-16606103 (+)
WSB/EiJ MGP_WSBEiJ_G0034723
 protein coding gene ChrX:16422380-16451954 (+)



Homology
more
  • Human Ortholog
    SLC6A14, solute carrier family 6 member 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC6A14, solute carrier family 6 member 14
  • Synonyms
    BMIQ11
  • Links
    NCBI Gene ID: 11254
    neXtProt AC: NX_Q9UN76
    UniProt: Q9UN76

  • Chr Location
    Xq23; chrX:116436606-116461458 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC6A14 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice hemizygous or homozygous for a null allele are viable, fertile and overtly normal. Homozygous females show normal plasma amino acid levels and mammary gland development but exhibit delayed development and reduced growth of mammary tumors in spontaneous mouse models of breast cancer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    47
  • cDNA Data
    22
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56774 NCBI Gene Model | MGI Sequence Detail 27459 C57BL/6J ±  kb
    transcript NM_020049 RefSeq | MGI Sequence Detail 3433 C57BL/6  
    polypeptide Q9JMA9 UniProt | EBI | MGI Sequence Detail 638 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000015180 sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
      (term hierarchy)
    • InterPro Domains
      IPR000175 Sodium:neurotransmitter symporter
      IPR037272 Sodium:neurotransmitter symporter superfamily
    • GlyGen
      Q9JMA9 7 sites
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1921088, MGI:1921782
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:64926 Sloan JL, et al., Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+). J Biol Chem. 1999 Aug 20;274(34):23740-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory