Akap10 MGI Mouse Gene Detail - MGI:1890218 - A kinase anchor protein 10

Symbol

Akap10
Name

A kinase anchor protein 10
Synonyms

1500031L16Rik, B130049N18Rik, D-AKAP2

Feature Type

protein coding gene
IDs

MGI:1890218
NCBI Gene: 56697
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:61762133-61821078 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.96 cM
Mapping Data

3 experiments

SNPs within 2kb

1199 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890218	protein coding gene	Chr11:61756029-61821134 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018448	protein coding gene	Chr11:61853191-61917439 (-)
A/J	MGP_AJ_G0018417	protein coding gene	Chr11:59590762-59649715 (-)
AKR/J	MGP_AKRJ_G0018387	protein coding gene	Chr11:61416983-61477344 (-)
BALB/cJ	MGP_BALBcJ_G0018388	protein coding gene	Chr11:59875588-59934524 (-)
C3H/HeJ	MGP_C3HHeJ_G0018201	protein coding gene	Chr11:61408442-61468538 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018840	protein coding gene	Chr11:63825162-63885177 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016486	protein coding gene	Chr11:56694254-56752824 (-)
CAST/EiJ	MGP_CASTEiJ_G0017758	protein coding gene	Chr11:61521575-61594963 (-)
CBA/J	MGP_CBAJ_G0018175	protein coding gene	Chr11:66595661-66659543 (-)
DBA/2J	MGP_DBA2J_G0018284	protein coding gene	Chr11:59142624-59200423 (-)
FVB/NJ	MGP_FVBNJ_G0018275	protein coding gene	Chr11:58823318-58886294 (-)
LP/J	MGP_LPJ_G0018357	protein coding gene	Chr11:62422355-62483210 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018299	protein coding gene	Chr11:67593768-67660574 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018881	protein coding gene	Chr11:61558477-61623734 (-)
PWK/PhJ	MGP_PWKPhJ_G0017531	protein coding gene	Chr11:59751444-59813434 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017321	protein coding gene	Chr11:61388258-61452733 (-)
WSB/EiJ	MGP_WSBEiJ_G0017810	protein coding gene	Chr11:61165591-61228254 (-)

Human Ortholog

AKAP10, A-kinase anchoring protein 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AKAP10, A-kinase anchoring protein 10
Synonyms

AKAP-10, D-AKAP-2, D-AKAP2, PRKA10
Links

HGNC:368

NCBI Gene ID: 11216

neXtProt AC: NX_O43572

UniProt: O43572
Chr Location

17p11.2; chr17:19904302-19978343 (-) GRCh38

MGI Vertebrate Homology

Akap10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AKAP10
Gene Tree

Akap10

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Phenotype Summary

12 phenotypes from 2 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Gene trapped

20
Targeted

2
Genomic Mutations

1 involving Akap10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele display sinus arrhythmia, sinus pauses, and atrioventricular heart block indicating excessive vagus nerve sensitivity; about 50% of homozygous and 25% of heterozygous mutant mice die in the first year of life, and survival is sensitive to genetic background.

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All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

60
cDNA Data

46
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AKAP10

Xenbase akap10

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All Sequences

46
RefSeq

5
UniProt

2
CCDS

CCDS24821.1

Ensembl

ENSMUSG00000047804 (Evidence)
NCBI Gene

56697

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047804	Ensembl Gene Model \| MGI Sequence Detail	58946	C57BL/6J	± kb
transcript	ENSMUST00000102650	Ensembl \| MGI Sequence Detail	3874	Not Applicable
polypeptide	ENSMUSP00000099710	Ensembl \| MGI Sequence Detail	662	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003884 A-kinase anchor protein 10, mitochondrial

(term hierarchy)
InterPro Domains

IPR037719 A-kinase anchor protein 10, PKA-binding (AKB) domain

IPR052246 Cell Polarization and PKA Anchoring

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR044926 RGS, subdomain 2
GlyGen

O88845 1 site, 1 O-linked glycan (1 site)

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All nucleic 50

cDNA 50

Microarray probesets 4

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MGI:1916263, MGI:2442725

Summaries

All 47

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Akap10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108388	Chr11:61821072-61821083 (-)	0 bp
Tssr108387	Chr11:61821023-61821069 (-)	32 bp
Tssr108386	Chr11:61817845-61817871 (-)	3,220 bp
Tssr108385	Chr11:61806019-61806034 (-)	15,051 bp
Tssr108384	Chr11:61805998-61805999 (-)	15,079 bp
Tssr108383	Chr11:61782473-61782489 (-)	38,597 bp
Tssr108382	Chr11:61769484-61769490 (-)	51,591 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24