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Gpr132 Gene Detail
Summary
  • Symbol
    Gpr132
  • Name
    G protein-coupled receptor 132
  • Synonyms
    G2a, G2 accumulation
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890220
    NCBI Gene: 56696
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:112814493-112831848 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.25 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    635 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890220
 protein coding gene Chr12:112814493-112832035 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020163
 protein coding gene Chr12:115326595-115339047 (-)
A/J MGP_AJ_G0020119
 protein coding gene Chr12:110872753-110882783 (-)
AKR/J MGP_AKRJ_G0020094
 protein coding gene Chr12:114087144-114097614 (-)
BALB/cJ MGP_BALBcJ_G0020104
 protein coding gene Chr12:111329263-111339283 (-)
C3H/HeJ MGP_C3HHeJ_G0019906
 protein coding gene Chr12:114594667-114604627 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020549
 protein coding gene Chr12:118889031-118899188 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018163
 protein coding gene Chr12:107306414-107317189 (-)
CAST/EiJ MGP_CASTEiJ_G0019446
 protein coding gene Chr12:109434913-109445853 (-)
CBA/J MGP_CBAJ_G0019873
 protein coding gene Chr12:123429612-123441301 (-)
DBA/2J MGP_DBA2J_G0019990
 protein coding gene Chr12:110363150-110374096 (-)
FVB/NJ MGP_FVBNJ_G0019975
 protein coding gene Chr12:109195041-109205739 (-)
LP/J MGP_LPJ_G0020064
 protein coding gene Chr12:115157020-115169631 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020013
 protein coding gene Chr12:126526482-126538682 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020578
 protein coding gene Chr12:113604423-113615266 (-)
PWK/PhJ MGP_PWKPhJ_G0019208
 protein coding gene Chr12:105022410-105032507 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019012
 protein coding gene Chr12:107776188-107786399 (-)
WSB/EiJ MGP_WSBEiJ_G0019506
 protein coding gene Chr12:114515322-114525338 (-)



Homology
more
  • Human Ortholog
    GPR132, G protein-coupled receptor 132
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR132, G protein-coupled receptor 132
  • Synonyms
    G2A
  • Links
    NCBI Gene ID: 29933
    neXtProt AC: NX_Q9UNW8
    UniProt: Q9UNW8

  • Chr Location
    14q32.33; chr14:105049395-105065445 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gpr132 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a generally normal phenotype but eventually develop a "late onset lymphoproliferative autoimmune syndrome"
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    54
  • cDNA Data
    16
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021298 Ensembl Gene Model | MGI Sequence Detail 17356 C57BL/6J ±  kb
    transcript ENSMUST00000021729 Ensembl | MGI Sequence Detail 2478 Not Applicable  
    polypeptide ENSMUSP00000021729 Ensembl | MGI Sequence Detail 382 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 3
      Phenotypes 24
    • Earliest
      J:64928 Weng Z, et al., A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12334-9
    • Latest
      J:356819 Wang JL, et al., Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab. 2023 Oct;5(10):1726-1746
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory