Midn MGI Mouse Gene Detail - MGI:1890222

Symbol

Midn
Name

midnolin
Synonyms

3000003C15Rik

Feature Type

protein coding gene
IDs

MGI:1890222
NCBI Gene: 59090
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr10:79984106-79994202 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

163 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890222	protein coding gene	Chr10:79984106-79994202 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017485	protein coding gene	Chr10:80733413-80743845 (+)
A/J	MGP_AJ_G0017463	protein coding gene	Chr10:77909922-77920108 (+)
AKR/J	MGP_AKRJ_G0017424	protein coding gene	Chr10:80038216-80048449 (+)
BALB/cJ	MGP_BALBcJ_G0017425	protein coding gene	Chr10:78133571-78143677 (+)
C3H/HeJ	MGP_C3HHeJ_G0017248	protein coding gene	Chr10:80136868-80146959 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017879	protein coding gene	Chr10:83516117-83526219 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015567	protein coding gene	Chr10:74135007-74145144 (+)
CAST/EiJ	MGP_CASTEiJ_G0016815	protein coding gene	Chr10:80339854-80352269 (+)
CBA/J	MGP_CBAJ_G0017220	protein coding gene	Chr10:86755387-86765513 (+)
DBA/2J	MGP_DBA2J_G0017326	protein coding gene	Chr10:77127917-77139923 (+)
FVB/NJ	MGP_FVBNJ_G0017320	protein coding gene	Chr10:76312183-76322604 (+)
LP/J	MGP_LPJ_G0017397	protein coding gene	Chr10:81212781-81223768 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017346	protein coding gene	Chr10:88706037-88715967 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017920	protein coding gene	Chr10:80018721-80028826 (+)
PWK/PhJ	MGP_PWKPhJ_G0016596	protein coding gene	Chr10:76994968-77005334 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016385	protein coding gene	Chr10:78999677-79009771 (+)
WSB/EiJ	MGP_WSBEiJ_G0016875	protein coding gene	Chr10:80052535-80064268 (+)

Human Ortholog

MIDN, midnolin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIDN, midnolin
Synonyms

Stx
Links

HGNC:16298

NCBI Gene ID: 90007

neXtProt AC: NX_Q504T8

UniProt: Q504T8
Chr Location

19p13.3; chr19:1248553-1259143 (+) GRCh38

MGI Vertebrate Homology

Midn stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MIDN
Gene Tree

Midn

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

19
Transgenic

1
Genomic Mutations

1 involving Midn
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transgenic gene disruption exhibit cleft palate and small ovary.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

25
cDNA Data

55
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase midn

ZFIN midn

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All Sequences

80
RefSeq

30
UniProt

5
CCDS

CCDS24011.1, CCDS83727.1

Ensembl

ENSMUSG00000035621 (Evidence)
NCBI Gene

59090

			Length	Strain/Species	Flank
genomic	59090	NCBI Gene Model \| MGI Sequence Detail	10097	C57BL/6J	± kb
transcript	NM_021565	RefSeq \| MGI Sequence Detail	3747	Not Specified
polypeptide	Q3TPJ7	UniProt \| EBI \| MGI Sequence Detail	465	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010409 midnolin

(term hierarchy)
InterPro Domains

IPR039336 Midnolin

IPR000626 Ubiquitin-like domain

IPR029071 Ubiquitin-like domain superfamily
GlyGen

Q3TPJ7 1 site, 1 O-linked glycan (1 site)

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All nucleic 56

cDNA 55

Primer pair 1

Microarray probesets 3

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MGI:1917443

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:349474 Zhong X, et al., Viable mutations of mouse midnolin suppress B cell malignancies. J Exp Med. 2024 Jun 3;221(6)

TSS for Midn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94496	Chr10:79983680-79983689 (+)	-421 bp
Tssr94497	Chr10:79984082-79984087 (+)	-21 bp
Tssr94498	Chr10:79984097-79984113 (+)	-1 bp
Tssr94499	Chr10:79985492-79985519 (+)	1,400 bp
Tssr94500	Chr10:79986282-79986316 (+)	2,193 bp
Tssr94501	Chr10:79986319-79986347 (+)	2,227 bp
Tssr94502	Chr10:79986646-79986659 (+)	2,547 bp
Tssr94503	Chr10:79986786-79986813 (+)	2,694 bp
Tssr94504	Chr10:79986817-79986834 (+)	2,720 bp
Tssr94505	Chr10:79987160-79987209 (+)	3,079 bp
Tssr94506	Chr10:79988245-79988282 (+)	4,158 bp
Tssr94507	Chr10:79989844-79989920 (+)	5,776 bp
Tssr94508	Chr10:79992562-79992597 (+)	8,474 bp
Tssr94509	Chr10:79992696-79992710 (+)	8,597 bp
Tssr94510	Chr10:79993783-79993791 (+)	9,681 bp
Tssr94511	Chr10:79993872-79993894 (+)	9,777 bp
Tssr94512	Chr10:79993959-79993963 (+)	9,855 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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