Fxyd6 MGI Mouse Gene Detail - MGI:1890226 - FXYD domain-containing ion transport regulator 6

Symbol

Fxyd6
Name

FXYD domain-containing ion transport regulator 6
Synonyms

0610030I18Rik, Php

Feature Type

protein coding gene
IDs

MGI:1890226
NCBI Gene: 59095
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr9:45281483-45307457 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM
Mapping Data

2 experiments

SNPs within 2kb

909 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890226	protein coding gene	Chr9:45280768-45307457 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034737	protein coding gene	Chr9:43928392-43955259 (+)
A/J	MGP_AJ_G0034718	protein coding gene	Chr9:42703867-42730039 (+)
AKR/J	MGP_AKRJ_G0034645	protein coding gene	Chr9:43578931-43604852 (+)
BALB/cJ	MGP_BALBcJ_G0034709	protein coding gene	Chr9:42431117-42457403 (+)
C3H/HeJ	MGP_C3HHeJ_G0034420	protein coding gene	Chr9:44035847-44062161 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035230	protein coding gene	Chr9:45213224-45243395 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032144	protein coding gene	Chr9:42248153-42274951 (+)
CAST/EiJ	MGP_CASTEiJ_G0033742	protein coding gene	Chr9:43896025-43922875 (+)
CBA/J	MGP_CBAJ_G0034392	protein coding gene	Chr9:46876562-46902506 (+)
DBA/2J	MGP_DBA2J_G0034551	protein coding gene	Chr9:42585364-42611923 (+)
FVB/NJ	MGP_FVBNJ_G0034492	protein coding gene	Chr9:41847431-41873949 (+)
LP/J	MGP_LPJ_G0034632	protein coding gene	Chr9:44232634-44261557 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034536	protein coding gene	Chr9:48675585-48701552 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035251	protein coding gene	Chr9:43501958-43527906 (+)
PWK/PhJ	MGP_PWKPhJ_G0033447	protein coding gene	Chr9:42475656-42502255 (+)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0033855	protein coding gene	Chr9:43530539-43557866 (+)

Human Ortholog

FXYD6, FXYD domain containing ion transport regulator 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FXYD6, FXYD domain containing ion transport regulator 6
Links

HGNC:4030

NCBI Gene ID: 53826

neXtProt AC: NX_Q9H0Q3

UniProt: Q9H0Q3
Chr Location

11q23.3; chr11:117836976-117877486 (-) GRCh38

MGI Vertebrate Homology

Fxyd6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FXYD6
Gene Tree

Fxyd6

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

51
Endonuclease-mediated

3
Gene trapped

48
Incidental Mutations

CvDC
Find Mice (IMSR)

11 strains or lines available

Mice homozygous for a null gene trap insertion exhibit impaired learning/memory during trace aversive conditioning when compared with that of their wild-type littermates.

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All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

34
cDNA Data

18
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fxyd6

ZFIN fxyd6

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All Sequences

53
RefSeq

8
UniProt

1
CCDS

CCDS23133.1

Ensembl

ENSMUSG00000066705 (Evidence)
NCBI Gene

59095

			Length	Strain/Species	Flank
genomic	ENSMUSG00000066705	Ensembl Gene Model \| MGI Sequence Detail	25975	C57BL/6J	± kb
transcript	ENSMUST00000085939	Ensembl \| MGI Sequence Detail	1788	Not Applicable
polypeptide	ENSMUSP00000083101	Ensembl \| MGI Sequence Detail	94	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031781 FXYD domain-containing ion transport regulator 6

(term hierarchy)
InterPro Domains

IPR000272 Ion-transport regulator, FXYD family

IPR047297 Ion-transport regulator, FXYD motif

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All nucleic 18

cDNA 18

Microarray probesets 3

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MGI:1913338

Summaries

All 47

Developmental Gene Expression 11

Gene Ontology 5

Phenotypes 6
Earliest

J:64123 Sweadner KJ, et al., The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Genomics. 2000 Aug 15;68(1):41-56
Latest

J:348785 Zhang D, et al., Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos. J Cell Physiol. 2024 Mar 26;

TSS for Fxyd6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84767	Chr9:45281301-45281317 (+)	-174 bp
Tssr84768	Chr9:45281390-45281407 (+)	-84 bp
Tssr84769	Chr9:45281497-45281506 (+)	19 bp
Tssr84770	Chr9:45281510-45281580 (+)	62 bp
Tssr84771	Chr9:45281695-45281761 (+)	245 bp
Tssr84772	Chr9:45282936-45282953 (+)	1,462 bp
Tssr84773	Chr9:45283004-45283029 (+)	1,534 bp
Tssr84775	Chr9:45301175-45301180 (+)	19,695 bp
Tssr84776	Chr9:45301189-45301204 (+)	19,714 bp
Tssr84777	Chr9:45301216-45301224 (+)	19,737 bp
Tssr84778	Chr9:45302045-45302061 (+)	20,570 bp
Tssr84779	Chr9:45302091-45302106 (+)	20,616 bp
Tssr84780	Chr9:45306383-45306419 (+)	24,918 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24