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Igf2bp2 Gene Detail
Summary
  • Symbol
    Igf2bp2
  • Name
    insulin-like growth factor 2 mRNA binding protein 2
  • Synonyms
    C330012H03Rik, IMP-2, IMP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890358
    NCBI Gene: 319765
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:21877759-21982049 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 13.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2848 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890358
 protein coding gene Chr16:21877759-21982049 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022666
 protein coding gene Chr16:19527700-19642027 (-)
A/J MGP_AJ_G0022628
 protein coding gene Chr16:18582596-18689086 (-)
AKR/J MGP_AKRJ_G0022603
 protein coding gene Chr16:19356395-19465942 (-)
BALB/cJ MGP_BALBcJ_G0022632
 protein coding gene Chr16:18782603-18887476 (-)
C3H/HeJ MGP_C3HHeJ_G0022397
 protein coding gene Chr16:19469416-19585707 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023083
 protein coding gene Chr16:19950356-20065127 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020601
 protein coding gene Chr16:19285917-19390234 (-)
CAST/EiJ MGP_CASTEiJ_G0021927
 protein coding gene Chr16:19448083-19561213 (-)
CBA/J MGP_CBAJ_G0022369
 protein coding gene Chr16:20775695-20899444 (-)
DBA/2J MGP_DBA2J_G0022501
 protein coding gene Chr16:18565244-18670315 (-)
FVB/NJ MGP_FVBNJ_G0022476
 protein coding gene Chr16:18536449-18640489 (-)
LP/J MGP_LPJ_G0022568
 protein coding gene Chr16:19272992-19387425 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022496
 protein coding gene Chr16:20353059-20465486 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023094
 protein coding gene Chr16:19309741-19419081 (-)
PWK/PhJ MGP_PWKPhJ_G0021667
 protein coding gene Chr16:18795449-18904958 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021497
 protein coding gene Chr16:19087668-19205359 (-)
WSB/EiJ MGP_WSBEiJ_G0021970
 protein coding gene Chr16:19271406-19382649 (-)



Homology
more
  • Human Ortholog
    IGF2BP2, insulin like growth factor 2 mRNA binding protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGF2BP2, insulin like growth factor 2 mRNA binding protein 2
  • Synonyms
    IMP-2, IMP2, VICKZ2
  • Links
    NCBI Gene ID: 10644
    neXtProt AC: NX_Q9Y6M1
    UniProt: Q9Y6M1

  • Chr Location
    3q27.2; chr3:185643130-185825042 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IGF2BP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased resistance to diet-induced obesity, decreased susceptibility to induced hypothermia and increased uncoupled oxygen consumption in adipocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    67
  • cDNA Data
    135
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 319765 NCBI Gene Model | MGI Sequence Detail 104291 C57BL/6J ±  kb
    transcript NM_183029 RefSeq | MGI Sequence Detail 3902 C57BL/6  
    polypeptide Q5SF07 UniProt | EBI | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 144
      cDNA 135
      Primer pair 8
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2442686
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 17
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:52252 Nielsen J, et al., A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. Mol Cell Biol. 1999 Feb;19(2):1262-70
    • Latest
      J:343459 Krumbein M, et al., RNA binding protein IGF2BP2 expression is induced by stress in the heart and mediates dilated cardiomyopathy. Commun Biol. 2023 Dec 5;6(1):1229
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory