Igf2bp3 MGI Mouse Gene Detail - MGI:1890359 - insulin-like growth factor 2 mRNA binding protein 3

Symbol

Igf2bp3
Name

insulin-like growth factor 2 mRNA binding protein 3
Synonyms

2610101N11Rik, IMP3, Koc13

Feature Type

protein coding gene
IDs

MGI:1890359
NCBI Gene: 140488
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr6:49062157-49191891 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 23.82 cM, cytoband B2.3
Mapping Data

5 experiments

SNPs within 2kb

3171 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890359	protein coding gene	Chr6:49062152-49200225 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030721	protein coding gene	Chr6:48070293-48213247 (-)
A/J	MGP_AJ_G0030692	protein coding gene	Chr6:45878183-46011604 (-)
AKR/J	MGP_AKRJ_G0030617	protein coding gene	Chr6:47494819-47634142 (-)
BALB/cJ	MGP_BALBcJ_G0030702	protein coding gene	Chr6:46217099-46347773 (-)
C3H/HeJ	MGP_C3HHeJ_G0030415	protein coding gene	Chr6:47498299-47641693 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031157	protein coding gene	Chr6:49203821-49345105 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028364	protein coding gene	Chr6:43490392-43620030 (-)
CAST/EiJ	MGP_CASTEiJ_G0029819	protein coding gene	Chr6:47223496-47357984 (-)
CBA/J	MGP_CBAJ_G0030390	protein coding gene	Chr6:51243895-51389552 (-)
DBA/2J	MGP_DBA2J_G0030539	protein coding gene	Chr6:45790278-45924641 (-)
FVB/NJ	MGP_FVBNJ_G0030491	protein coding gene	Chr6:45432698-45565947 (-)
LP/J	MGP_LPJ_G0030624	protein coding gene	Chr6:48052335-48191470 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030525	protein coding gene	Chr6:54008348-54154333 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031186	protein coding gene	Chr6:47359316-47496607 (-)
PWK/PhJ	MGP_PWKPhJ_G0029531	protein coding gene	Chr6:45336791-45470964 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029367	protein coding gene	Chr6:46704949-46844717 (-)
WSB/EiJ	MGP_WSBEiJ_G0029896	protein coding gene	Chr6:47359315-47495573 (-)

Human Ortholog

IGF2BP3, insulin like growth factor 2 mRNA binding protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IGF2BP3, insulin like growth factor 2 mRNA binding protein 3
Synonyms

CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3
Links

HGNC:28868

NCBI Gene ID: 10643

neXtProt AC: NX_O00425

UniProt: O00425
Chr Location

7p15.3; chr7:23310209-23470491 (-) GRCh38

MGI Vertebrate Homology

Igf2bp3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IGF2BP3
Gene Tree

Igf2bp3

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Endonuclease-mediated

5
Gene trapped

48
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available

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All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

78
cDNA Data

17
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA IGF2BP3

Xenbase igf2bp3

ZFIN igf2bp3

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All Sequences

55
RefSeq

9
UniProt

2
CCDS

CCDS39485.1

Ensembl

ENSMUSG00000029814 (Evidence)
NCBI Gene

140488

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029814	Ensembl Gene Model \| MGI Sequence Detail	129735	C57BL/6J	± kb
transcript	ENSMUST00000031838	Ensembl \| MGI Sequence Detail	4345	Not Applicable
polypeptide	ENSMUSP00000031838	Ensembl \| MGI Sequence Detail	579	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008945 insulin-like growth factor 2 mRNA-binding protein 3

(term hierarchy)
PDB

7VKL, 7VSJ, 7YEW, 7YEX, 7YEY
InterPro Domains

IPR019844 Cold-shock (CSD) domain

IPR011129 Cold shock domain

IPR050181 Cold shock domain-containing protein

IPR002059 Cold-shock protein, DNA-binding

IPR004087 K Homology domain

IPR004088 K Homology domain, type 1

IPR036612 K Homology domain, type 1 superfamily

IPR012340 Nucleic acid-binding, OB-fold

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

Q9CPN8 1 site, 1 O-linked glycan (1 site)

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All nucleic 27

Genomic 3

cDNA 19

Primer pair 4

Other 1

Microarray probesets 7

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MGI:1919721, MGI:2141367, MGI:2141534, MGI:2141597

Summaries

All 59

Developmental Gene Expression 12

Gene Ontology 7

Phenotypes 11
Earliest

J:30335 Duh JL, et al., The Y-box motif mediates redox-dependent transcriptional activation in mouse cells. J Biol Chem. 1995 Dec 22;270(51):30499-507
Latest

J:346346 Yuan D, et al., IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy. Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870(3):167022

TSS for Igf2bp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr60881	Chr6:49192346-49192404 (-)	-484 bp
Tssr60880	Chr6:49192295-49192311 (-)	-412 bp
Tssr60879	Chr6:49191947-49191956 (-)	-61 bp
Tssr60878	Chr6:49191781-49191790 (-)	105 bp
Tssr60877	Chr6:49191752-49191761 (-)	134 bp
Tssr60876	Chr6:49191659-49191682 (-)	220 bp
Tssr60875	Chr6:49191632-49191655 (-)	247 bp
Tssr60874	Chr6:49191599-49191610 (-)	286 bp
Tssr60873	Chr6:49191519-49191526 (-)	368 bp
Tssr60872	Chr6:49191095-49191113 (-)	787 bp
Tssr60870	Chr6:49088052-49088071 (-)	103,829 bp
Tssr60869	Chr6:49088017-49088034 (-)	103,865 bp
Tssr60868	Chr6:49087987-49087993 (-)	103,901 bp
Tssr60867	Chr6:49087936-49087946 (-)	103,950 bp
Tssr60866	Chr6:49087909-49087932 (-)	103,970 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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