Fscn3 MGI Mouse Gene Detail - MGI:1890386 - fascin actin-bundling protein 3

Symbol

Fscn3
Name

fascin actin-bundling protein 3

Feature Type

protein coding gene
IDs

MGI:1890386
NCBI Gene: 56223
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:28427888-28438621 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 11.99 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

369 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890386	protein coding gene	Chr6:28427788-28438621 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030509	protein coding gene	Chr6:26155038-26166512 (+)
A/J	MGP_AJ_G0030482	protein coding gene	Chr6:25049568-25061562 (+)
AKR/J	MGP_AKRJ_G0030409	protein coding gene	Chr6:25877731-25891386 (+)
BALB/cJ	MGP_BALBcJ_G0030492	protein coding gene	Chr6:25213510-25224825 (+)
C3H/HeJ	MGP_C3HHeJ_G0030205	protein coding gene	Chr6:25862329-25874379 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030946	protein coding gene	Chr6:26952254-26963253 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028157	protein coding gene	Chr6:23280280-23291054 (+)
CAST/EiJ	MGP_CASTEiJ_G0029607	protein coding gene	Chr6:25670474-25684214 (+)
CBA/J	MGP_CBAJ_G0030183	protein coding gene	Chr6:27917477-27929870 (+)
DBA/2J	MGP_DBA2J_G0030327	protein coding gene	Chr6:25005246-25015740 (+)
FVB/NJ	MGP_FVBNJ_G0030281	protein coding gene	Chr6:24757131-24767743 (+)
LP/J	MGP_LPJ_G0030414	protein coding gene	Chr6:26288659-26300213 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030317	protein coding gene	Chr6:30474301-30487917 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030976	protein coding gene	Chr6:25756496-25767668 (+)
PWK/PhJ	MGP_PWKPhJ_G0029321	protein coding gene	Chr6:24533683-24545028 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029157	protein coding gene	Chr6:25452095-25464991 (+)
WSB/EiJ	MGP_WSBEiJ_G0029683	protein coding gene	Chr6:25724609-25735750 (+)

Human Ortholog

FSCN3, fascin actin-bundling protein 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FSCN3, fascin actin-bundling protein 3
Links

HGNC:3961

NCBI Gene ID: 29999

neXtProt AC: NX_Q9NQT6

UniProt: Q9NQT6
Chr Location

7q32.1; chr7:127591409-127602144 (+) GRCh38

MGI Vertebrate Homology

Fscn3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FSCN3
Protein SuperFamily

Fascin
Gene Tree

Fscn3

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

Mice homozygous for a null mutation are viable and fertile. No defects in sperm morphology or spermatogenesis are seen.

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All GO Annotations

21
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

4
cDNA Data

6
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

30
RefSeq

4
UniProt

1
CCDS

CCDS39446.1

Ensembl

ENSMUSG00000029707 (Evidence)
NCBI Gene

56223

			Length	Strain/Species	Flank
genomic	56223	NCBI Gene Model \| MGI Sequence Detail	10734	C57BL/6J	± kb
transcript	NM_019569	RefSeq \| MGI Sequence Detail	1802	C57BL/6
polypeptide	Q9QXW4	UniProt \| EBI \| MGI Sequence Detail	498	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007679 fascin-3

(term hierarchy)
InterPro Domains

IPR008999 Actin-crosslinking

IPR010431 Fascin

IPR022768 Fascin domain

IPR024703 Fascin, metazoans

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 2

Summaries

All 22

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 3
Earliest

J:75979 Tubb B, et al., Testis Fascin (FSCN3): A Novel Paralog of the Actin-Bundling Protein Fascin Expressed Specifically in the Elongate Spermatid Head. Exp Cell Res. 2002 Apr 15;275(1):92-109
Latest

J:345144 Ali H, et al., Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility. Mol Biol Rep. 2022 Jul;49(7):6261-6268

TSS for Fscn3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55193	Chr6:28426232-28426264 (+)	-1,640 bp
Tssr55194	Chr6:28426293-28426319 (+)	-1,582 bp
Tssr55195	Chr6:28426342-28426353 (+)	-1,540 bp
Tssr55196	Chr6:28426378-28426389 (+)	-1,504 bp
Tssr55197	Chr6:28426491-28426500 (+)	-1,392 bp
Tssr55198	Chr6:28427881-28427908 (+)	7 bp
Tssr55199	Chr6:28427917-28427924 (+)	33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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