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Slc15a2 Gene Detail
Summary
  • Symbol
    Slc15a2
  • Name
    solute carrier family 15 (H+/peptide transporter), member 2
  • Synonyms
    8430408C16Rik, Pept2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890457
    NCBI Gene: 57738
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36570539-36605324 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 25.97 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    761 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890457
 protein coding gene Chr16:36570523-36605506 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022792
 protein coding gene Chr16:35156441-35192265 (-)
A/J MGP_AJ_G0022757
 protein coding gene Chr16:33434651-33465228 (-)
AKR/J MGP_AKRJ_G0022729
 protein coding gene Chr16:34709038-34748300 (-)
BALB/cJ MGP_BALBcJ_G0022758
 protein coding gene Chr16:33537431-33567254 (-)
C3H/HeJ MGP_C3HHeJ_G0022522
 protein coding gene Chr16:34827998-34859134 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023205
 protein coding gene Chr16:36005285-36042060 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020719
 protein coding gene Chr16:33796822-33828350 (-)
CAST/EiJ MGP_CASTEiJ_G0022048
 protein coding gene Chr16:34943492-34977240 (-)
CBA/J MGP_CBAJ_G0022493
 protein coding gene Chr16:37577087-37608361 (-)
DBA/2J MGP_DBA2J_G0022625
 protein coding gene Chr16:33327075-33357011 (-)
FVB/NJ MGP_FVBNJ_G0022600
 protein coding gene Chr16:33360237-33391985 (-)
LP/J MGP_LPJ_G0022693
 protein coding gene Chr16:34873734-34905253 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022619
 protein coding gene Chr16:36612327-36643540 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023220
 protein coding gene Chr16:34657955-34687419 (-)
PWK/PhJ MGP_PWKPhJ_G0021788
 protein coding gene Chr16:33726464-33758093 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021619
 protein coding gene Chr16:34578314-34607558 (-)
WSB/EiJ MGP_WSBEiJ_G0022092
 protein coding gene Chr16:34714624-34746155 (-)



Homology
more
  • Human Ortholog
    SLC15A2, solute carrier family 15 member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC15A2, solute carrier family 15 member 2
  • Synonyms
    PEPT2
  • Links
    NCBI Gene ID: 6565
    neXtProt AC: NX_Q16348
    UniProt: Q16348

  • Chr Location
    3q13.33; chr3:121894401-121944188 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice have impairments of dipeptide transportion, however, show no gross defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    900
  • Tissues
    100
  • cDNA Data
    54
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022899 Ensembl Gene Model | MGI Sequence Detail 34786 C57BL/6J ±  kb
transcript ENSMUST00000023616 Ensembl | MGI Sequence Detail 3994 Not Applicable  
polypeptide ENSMUSP00000023616 Ensembl | MGI Sequence Detail 740 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000014941 solute carrier family 15 member 2
    (term hierarchy)
  • InterPro Domains
    IPR029028 Alpha/beta knot methyltransferases
    IPR036259 MFS transporter superfamily
    IPR004768 Oligopeptide transporter
    IPR000109 Proton-dependent oligopeptide transporter family
    IPR018456 PTR2 family proton/oligopeptide symporter, conserved site
  • GlyGen
    Q9ES07 5 sites, 4 N-linked glycans (4 sites)
Molecular
Reagents
less
  • All nucleic 56
    cDNA 54
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:1918747, MGI:2146702
References
more
  • Summaries
    All 54
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 19
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:350133 Nies AT, et al., Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation. Pharmacol Res. 2023 Oct;196:106941
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory