Ear6 MGI Mouse Gene Detail - MGI:1890463 - eosinophil-associated, ribonuclease A family, member 6

Symbol

Ear6
Name

eosinophil-associated, ribonuclease A family, member 6

Feature Type

protein coding gene
IDs

MGI:1890463
NCBI Gene: 93719
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr14:52091225-52092100 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.70 cM, cytoband B-C1
Mapping Data

2 experiments

SNPs within 2kb

229 from dbSNP Build 142
Strain Annotations

11

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890463	protein coding gene	Chr14:52091156-52092100 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021280	protein coding gene	Chr14:45863088-45863955 (+)
A/J	MGP_AJ_G0021237	protein coding gene	Chr14:44685559-44686426 (+)
AKR/J	MGP_AKRJ_G0021213	protein coding gene	Chr14:46289131-46289998 (+)
BALB/cJ	MGP_BALBcJ_G0021241	protein coding gene	Chr14:44778395-44779262 (+)
C3H/HeJ	MGP_C3HHeJ_G0021021	protein coding gene	Chr14:46092518-46093385 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021680	protein coding gene	Chr14:47881130-47882074 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0020988	protein coding gene	Chr14:49334505-49335372 (+)
DBA/2J	MGP_DBA2J_G0021109	protein coding gene	Chr14:44451283-44452150 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0021184	protein coding gene	Chr14:46448384-46449251 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0021707	protein coding gene	Chr14:45642189-45643135 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

RNASE2, ribonuclease A family member 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNASE2, ribonuclease A family member 2
Synonyms

EDN, RAF3, RNS2
Links

HGNC:10045

NCBI Gene ID: 6036

neXtProt AC: NX_P10153

UniProt: P10153
Chr Location

14q11.2; chr14:20955487-20956436 (+) GRCh38

Human Ortholog

RNASE3, ribonuclease A family member 3
Synonyms

ECP, RAF1, RNS3
Links

HGNC:10046

NCBI Gene ID: 6037

neXtProt AC: NX_P12724

UniProt: P12724
Chr Location

14q11.2; chr14:20891385-20892348 (+) GRCh38

MGI Vertebrate Homology

Ear6 stringent orthology
2 human;1 mouse;2 rat
HCOP

vertebrate homology predictions: RNASE2, RNASE3
Gene Tree

Ear6

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

3
Genomic Mutations

1 involving Ear6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

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All GO Annotations

10
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

26
RefSeq

2
UniProt

1
CCDS

CCDS27045.1

Ensembl

ENSMUSG00000062148 (Evidence)
NCBI Gene

93719

			Length	Strain/Species	Flank
genomic	93719	NCBI Gene Model \| MGI Sequence Detail	876	C57BL/6J	± kb
transcript	NM_053111	RefSeq \| MGI Sequence Detail	738	C57BL/6
polypeptide	NP_444341	RefSeq \| MGI Sequence Detail	155	C57BL/6

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UniProt

1 Sequence
InterPro Domains

IPR001427 Pancreatic ribonuclease

IPR023411 Ribonuclease A, active site

IPR023412 Ribonuclease A-domain

IPR036816 Ribonuclease A-like domain superfamily
GlyGen

Q923L7 1 site, 1 N-linked glycan (1 site)

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All nucleic 5

cDNA 5

Microarray probesets 1

Summaries

All 24

Gene Ontology 3

Phenotypes 6
Earliest

J:69087 Cormier SA, et al., Mouse eosinophil-associated ribonucleases: a unique subfamily expressed during hematopoiesis. Mamm Genome. 2001 May;12(5):352-61
Latest

J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

TSS for Ear6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125427	Chr14:52091224-52091229 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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