Pcbp4 MGI Mouse Gene Detail - MGI:1890471 - poly(rC) binding protein 4

Symbol

Pcbp4
Name

poly(rC) binding protein 4
Synonyms

1200003L19Rik, AlphaCP-4

Feature Type

protein coding gene
IDs

MGI:1890471
NCBI Gene: 59092
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr9:106330490-106341211 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 57.54 cM, cytoband F1-F2
Mapping Data

2 experiments

SNPs within 2kb

236 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890471	protein coding gene	Chr9:106330181-106341211 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035232	protein coding gene	Chr9:108263883-108273775 (+)
A/J	MGP_AJ_G0035211	protein coding gene	Chr9:104349817-104360322 (+)
AKR/J	MGP_AKRJ_G0035143	protein coding gene	Chr9:106949110-106961066 (+)
BALB/cJ	MGP_BALBcJ_G0035205	protein coding gene	Chr9:104035383-104045914 (+)
C3H/HeJ	MGP_C3HHeJ_G0034915	protein coding gene	Chr9:107361309-107375393 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035725	protein coding gene	Chr9:111245840-111258417 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032623	protein coding gene	Chr9:101840391-101850782 (+)
CAST/EiJ	MGP_CASTEiJ_G0034226	protein coding gene	Chr9:107264160-107279597 (+)
CBA/J	MGP_CBAJ_G0034883	protein coding gene	Chr9:115173994-115192972 (+)
DBA/2J	MGP_DBA2J_G0035044	protein coding gene	Chr9:103811770-103823042 (+)
FVB/NJ	MGP_FVBNJ_G0034992	protein coding gene	Chr9:102590846-102602159 (+)
LP/J	MGP_LPJ_G0035120	protein coding gene	Chr9:108483119-108495569 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035031	protein coding gene	Chr9:116773327-116784783 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035746	protein coding gene	Chr9:107196379-107207359 (+)
PWK/PhJ	MGP_PWKPhJ_G0033933	protein coding gene	Chr9:104110153-104121765 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033768	protein coding gene	Chr9:107266783-107278351 (+)
WSB/EiJ	MGP_WSBEiJ_G0034347	protein coding gene	Chr9:107095849-107106379 (+)

Human Ortholog

PCBP4, poly(rC) binding protein 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PCBP4, poly(rC) binding protein 4
Synonyms

CBP, LIP4, MCG10
Links

HGNC:8652

NCBI Gene ID: 57060

neXtProt AC: NX_P57723

UniProt: P57723
Chr Location

3p21.2; chr3:51957454-51974016 (-) GRCh38

MGI Vertebrate Homology

Pcbp4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PCBP4
Gene Tree

Pcbp4

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

46
Gene trapped

42
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous or heterozygous for a knock-out allele are reduced in body weight and prone to lung adenocarcinoma, B cell derived lymphoma and lung tumors.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

772
Tissues

32
cDNA Data

119
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN pcbp4

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All Sequences

126
RefSeq

20
UniProt

17
CCDS

CCDS23479.1

Ensembl

ENSMUSG00000023495 (Evidence)
NCBI Gene

59092

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023495	Ensembl Gene Model \| MGI Sequence Detail	10722	C57BL/6J	± kb
transcript	ENSMUST00000024260	Ensembl \| MGI Sequence Detail	2035	Not Applicable
polypeptide	ENSMUSP00000024260	Ensembl \| MGI Sequence Detail	403	Not Applicable

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UniProt

17 Sequences
Protein Ontology

PR:000012338 poly(rC)-binding protein 4

(term hierarchy)
InterPro Domains

IPR004087 K Homology domain

IPR004088 K Homology domain, type 1

IPR036612 K Homology domain, type 1 superfamily

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All nucleic 122

cDNA 121

Primer pair 1

Microarray probesets 5

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MGI:1914112

Summaries

All 35

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 9
Earliest

J:63824 Makeyev AV, et al., Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins. Genomics. 2000 Aug 1;67(3):301-16
Latest

J:243411 Rutledge EA, et al., Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Development. 2017 Sep 01;144(17):3177-3188

TSS for Pcbp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86900	Chr9:106329278-106329296 (+)	-1,203 bp
Tssr86901	Chr9:106329346-106329364 (+)	-1,135 bp
Tssr86902	Chr9:106329377-106329393 (+)	-1,105 bp
Tssr86903	Chr9:106330440-106330475 (+)	-32 bp
Tssr86904	Chr9:106330552-106330612 (+)	92 bp
Tssr86905	Chr9:106330613-106330634 (+)	134 bp
Tssr86906	Chr9:106331079-106331110 (+)	605 bp
Tssr86907	Chr9:106331111-106331132 (+)	632 bp
Tssr86908	Chr9:106331133-106331144 (+)	649 bp
Tssr86909	Chr9:106331146-106331160 (+)	663 bp
Tssr86910	Chr9:106331446-106331457 (+)	962 bp
Tssr86911	Chr9:106337822-106337845 (+)	7,344 bp
Tssr86912	Chr9:106337849-106337856 (+)	7,363 bp
Tssr86913	Chr9:106337889-106337897 (+)	7,403 bp
Tssr86914	Chr9:106339083-106339094 (+)	8,599 bp
Tssr86915	Chr9:106340352-106340403 (+)	9,888 bp
Tssr86916	Chr9:106340456-106340471 (+)	9,974 bp
Tssr86917	Chr9:106340579-106340611 (+)	10,105 bp
Tssr86918	Chr9:106340712-106340750 (+)	10,241 bp
Tssr86919	Chr9:106340982-106341015 (+)	10,509 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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