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Il19 Gene Detail
Summary
  • Symbol
    Il19
  • Name
    interleukin 19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890472
    NCBI Gene: 329244
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr1:130860393-130867852 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    292 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890472
 protein coding gene Chr1:130860393-130873194 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016446
 protein coding gene Chr1:134338431-134346210 (-)
A/J MGP_AJ_G0016429
 protein coding gene Chr1:129370811-129378270 (-)
AKR/J MGP_AKRJ_G0016394
 protein coding gene Chr1:133179327-133186776 (-)
BALB/cJ MGP_BALBcJ_G0016389
 protein coding gene Chr1:129698608-129706032 (-)
C3H/HeJ MGP_C3HHeJ_G0016215
 protein coding gene Chr1:133316714-133324183 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016850
 protein coding gene Chr1:139336280-139343777 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014564
 protein coding gene Chr1:122510338-122517662 (-)
CAST/EiJ MGP_CASTEiJ_G0015795
 protein coding gene Chr1:132308879-132316335 (-)
CBA/J MGP_CBAJ_G0016187
 protein coding gene Chr1:144127999-144135419 (-)
DBA/2J MGP_DBA2J_G0016294
 protein coding gene Chr1:128332951-128340396 (-)
FVB/NJ MGP_FVBNJ_G0016293
 protein coding gene Chr1:126975978-126983386 (-)
LP/J MGP_LPJ_G0016365
 protein coding gene Chr1:135651838-135659232 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016318
 protein coding gene Chr1:149903950-149911358 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016886
 protein coding gene Chr1:132943392-132950812 (-)
PWK/PhJ MGP_PWKPhJ_G0015581
 protein coding gene Chr1:127303189-127311154 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015368
 protein coding gene Chr1:131878647-131886105 (-)
WSB/EiJ MGP_WSBEiJ_G0015857
 protein coding gene Chr1:132932536-132941214 (-)



Homology
more
  • Human Ortholog
    IL19, interleukin 19
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL19, interleukin 19
  • Synonyms
    IL-10C, MDA1, NG.1, ZMDA1
  • Links
    NCBI Gene ID: 29949
    neXtProt AC: NX_Q9UHD0
    UniProt: Q9UHD0

  • Chr Location
    1q32.1; chr1:206770764-206842981 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit interleukin-23 (IL-23)-dependent epidermal hyperplasia. Mice homozygous for a different knock-out allele exhibit increased susceptibility to induced colitis with reduced B cell infiltration in chronic colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016524 Ensembl Gene Model | MGI Sequence Detail 7460 C57BL/6J ±  kb
    transcript ENSMUST00000112465 Ensembl | MGI Sequence Detail 880 Not Applicable  
    polypeptide ENSMUSP00000108084 Ensembl | MGI Sequence Detail 176 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1
      cDNA 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:331108 He Y, et al., IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer. J Clin Invest. 2022 Oct 17;132(20):e157917
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory