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Rad18 Gene Detail
Summary
  • Symbol
    Rad18
  • Name
    RAD18 E3 ubiquitin protein ligase
  • Synonyms
    2810024C04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890476
    NCBI Gene: 58186
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:112596811-112673647 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.42 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1943 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890476
 protein coding gene Chr6:112596811-112673650 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031109
 protein coding gene Chr6:115078774-115156591 (-)
A/J MGP_AJ_G0031078
 protein coding gene Chr6:110682837-110757560 (-)
AKR/J MGP_AKRJ_G0031009
 protein coding gene Chr6:113671877-113746856 (-)
BALB/cJ MGP_BALBcJ_G0031089
 protein coding gene Chr6:110639616-110715286 (-)
C3H/HeJ MGP_C3HHeJ_G0030619
 protein coding gene Chr6:70563853-70636319 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031548
 protein coding gene Chr6:118082796-118154715 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028712
 protein coding gene Chr6:107699417-107773095 (-)
CAST/EiJ MGP_CASTEiJ_G0030196
 protein coding gene Chr6:114094497-114168068 (-)
CBA/J MGP_CBAJ_G0030775
 protein coding gene Chr6:122742917-122821509 (-)
DBA/2J MGP_DBA2J_G0030928
 protein coding gene Chr6:109784507-109855136 (-)
FVB/NJ MGP_FVBNJ_G0030882
 protein coding gene Chr6:108775869-108848040 (-)
LP/J MGP_LPJ_G0031008
 protein coding gene Chr6:115125406-115211467 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030916
 protein coding gene Chr6:127050520-127125887 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031575
 protein coding gene Chr6:113673225-113747500 (-)
PWK/PhJ MGP_PWKPhJ_G0029912
 protein coding gene Chr6:108720989-108792669 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029740
 protein coding gene Chr6:112486840-112559627 (-)
WSB/EiJ MGP_WSBEiJ_G0030280
 protein coding gene Chr6:114049132-114122163 (-)



Homology
more
  • Human Ortholog
    RAD18, RAD18 E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD18, RAD18 E3 ubiquitin protein ligase
  • Synonyms
    RNF73
  • Links
    NCBI Gene ID: 56852
    neXtProt AC: NX_Q9NS91
    UniProt: Q9NS91

  • Chr Location
    3p25.3; chr3:8775402-8963773 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 4 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele exhibit age-dependent decrease in fertility, germ cell number, and testes weight with progressive degeneration of seminiferous tubules.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    25
  • cDNA Data
    45
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030254 Ensembl Gene Model | MGI Sequence Detail 76837 C57BL/6J ±  kb
    transcript ENSMUST00000068487 Ensembl | MGI Sequence Detail 2577 Not Applicable  
    polypeptide ENSMUSP00000070619 Ensembl | MGI Sequence Detail 556 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 1
      cDNA 46
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919872
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 24
    • Earliest
      J:65085 van der Laan R, et al., Characterization of mRAD18Sc, a mouse homolog of the yeast postreplication repair gene RAD18. Genomics. 2000 Oct 1;69(1):86-94
    • Latest
      J:346582 Kalweit K, et al., Role of Rad18 in B cell activation and lymphomagenesis. Sci Rep. 2024 Mar 25;14(1):7066
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory