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Plin1 Gene Detail
Summary
  • Symbol
    Plin1
  • Name
    perilipin 1
  • Synonyms
    6030432J05Rik, Peri, perilipin A, perilipin B, Plin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890505
    NCBI Gene: 103968
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79370912-79382652 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    358 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890505
 protein coding gene Chr7:79369966-79382652 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032393
 protein coding gene Chr7:81624349-81639015 (-)
A/J MGP_AJ_G0032372
 protein coding gene Chr7:79736412-79750490 (-)
AKR/J MGP_AKRJ_G0032308
 protein coding gene Chr7:81441641-81454364 (-)
BALB/cJ MGP_BALBcJ_G0032384
 protein coding gene Chr7:79428556-79441863 (-)
C3H/HeJ MGP_C3HHeJ_G0032097
 protein coding gene Chr7:82103810-82118236 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032876
 protein coding gene Chr7:84824473-84843907 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029884
 protein coding gene Chr7:82275500-82288928 (-)
CAST/EiJ MGP_CASTEiJ_G0031425
 protein coding gene Chr7:72979417-72995021 (-)
CBA/J MGP_CBAJ_G0032063
 protein coding gene Chr7:87667549-87680507 (-)
DBA/2J MGP_DBA2J_G0032218
 protein coding gene Chr7:78306389-78319822 (-)
FVB/NJ MGP_FVBNJ_G0032173
 protein coding gene Chr7:78220422-78233151 (-)
LP/J MGP_LPJ_G0032299
 protein coding gene Chr7:82879559-82894048 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032210
 protein coding gene Chr7:87834860-87848428 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032894
 protein coding gene Chr7:80898486-80913983 (-)
PWK/PhJ MGP_PWKPhJ_G0031145
 protein coding gene Chr7:71480767-71494485 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030986
 protein coding gene Chr7:67896044-67914734 (-)
WSB/EiJ MGP_WSBEiJ_G0031543
 protein coding gene Chr7:81218966-81232975 (-)



Homology
more
  • Human Ortholog
    PLIN1, perilipin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLIN1, perilipin 1
  • Synonyms
    FPLD4, PERI, PLIN
  • Links
    NCBI Gene ID: 5346
    neXtProt AC: NX_O60240
    UniProt: O60240

  • Chr Location
    15q26.1; chr15:89664367-89679427 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PLIN1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 5 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to increased lean body mass and altered adipocyte lipolysis, leptin production and susceptibility to diet-induced obesity. Increased oxygen and food consumption, impaired cold adaptation, and altered glucose andblood homeostasis have also been observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    20
  • cDNA Data
    23
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 103968 NCBI Gene Model | MGI Sequence Detail 11741 C57BL/6J ±  kb
    transcript NM_175640 RefSeq | MGI Sequence Detail 1935 C57BL/6  
    polypeptide Q8CGN5 UniProt | EBI | MGI Sequence Detail 517 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 23
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2444270
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 26
      Gene Ontology 7
      Phenotypes 34
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:354440 McClure JJ, et al., Disentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee. Osteoarthritis Cartilage. 2024 Aug 3;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory