Panx2 MGI Mouse Gene Detail - MGI:1890615

Symbol

Panx2
Name

pannexin 2

Feature Type

protein coding gene
IDs

MGI:1890615
NCBI Gene: 406218
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:88943937-88957770 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 44.57 cM
Mapping Data

1 experiment

SNPs within 2kb

360 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890615	protein coding gene	Chr15:88941797-88957770 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022214	protein coding gene	Chr15:90222340-90239372 (+)
A/J	MGP_AJ_G0022173	protein coding gene	Chr15:86777153-86790945 (+)
AKR/J	MGP_AKRJ_G0022148	protein coding gene	Chr15:89348300-89362105 (+)
BALB/cJ	MGP_BALBcJ_G0022179	protein coding gene	Chr15:86879453-86894315 (+)
C3H/HeJ	MGP_C3HHeJ_G0021949	protein coding gene	Chr15:89334330-89349210 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022624	protein coding gene	Chr15:93510654-93526227 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020149	protein coding gene	Chr15:83005163-83018850 (+)
CAST/EiJ	MGP_CASTEiJ_G0021471	protein coding gene	Chr15:90114353-90128099 (+)
CBA/J	MGP_CBAJ_G0021916	protein coding gene	Chr15:96670774-96684620 (+)
DBA/2J	MGP_DBA2J_G0022043	protein coding gene	Chr15:86234891-86248940 (+)
FVB/NJ	MGP_FVBNJ_G0022022	protein coding gene	Chr15:85298566-85312942 (+)
LP/J	MGP_LPJ_G0022114	protein coding gene	Chr15:90391718-90406874 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022042	protein coding gene	Chr15:101092583-101106333 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022639	protein coding gene	Chr15:89381788-89396583 (+)
PWK/PhJ	MGP_PWKPhJ_G0021212	protein coding gene	Chr15:86278545-86292546 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021046	protein coding gene	Chr15:89115895-89131095 (+)
WSB/EiJ	MGP_WSBEiJ_G0021520	protein coding gene	Chr15:89866190-89881144 (+)

Human Ortholog

PANX2, pannexin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PANX2, pannexin 2
Synonyms

hPANX2, PX2
Links

HGNC:8600

NCBI Gene ID: 56666

neXtProt AC: NX_Q96RD6

UniProt: Q96RD6
Chr Location

22q13.33; chr22:50170731-50180295 (+) GRCh38

MGI Vertebrate Homology

Panx2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PANX2
Gene Tree

Panx2

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
2 images
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Panx2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit a slight protection from the neurological defects induced by ischemic brain injury.

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All GO Annotations

18
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

768
Tissues

34
cDNA Data

2
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase panx2

ZFIN panx2

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All Sequences

41
RefSeq

6
UniProt

2
CCDS

CCDS49695.1

Ensembl

ENSMUSG00000058441 (Evidence)
NCBI Gene

406218

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058441	Ensembl Gene Model \| MGI Sequence Detail	13834	C57BL/6J	± kb
transcript	ENSMUST00000162424	Ensembl \| MGI Sequence Detail	3391	Not Applicable
polypeptide	ENSMUSP00000124354	Ensembl \| MGI Sequence Detail	677	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012260 pannexin-2

(term hierarchy)
InterPro Domains

IPR000990 Innexin

IPR039099 Pannexin
GlyGen

Q6IMP4 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 4

cDNA 2

Primer pair 2

Microarray probesets 4

Summaries

All 56

Developmental Gene Expression 4

Diseases 1

Gene Ontology 9

Phenotypes 31
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Panx2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132633	Chr15:88943915-88943963 (+)	2 bp
Tssr132634	Chr15:88943964-88943985 (+)	38 bp
Tssr132635	Chr15:88943988-88944007 (+)	61 bp
Tssr132636	Chr15:88944271-88944303 (+)	350 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24