Donson MGI Mouse Gene Detail - MGI:1890621 - downstream neighbor of SON

Symbol

Donson
Name

downstream neighbor of SON
Synonyms

1110025J21Rik, Donson, ORF60

Feature Type

protein coding gene
IDs

MGI:1890621
NCBI Gene: 60364
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr16:91473696-91485658 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 53.25 cM
Mapping Data

2 experiments

SNPs within 2kb

297 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890621	protein coding gene	Chr16:91463744-91485702 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023047	protein coding gene	Chr16:92707778-92719275 (-)
A/J	MGP_AJ_G0023015	protein coding gene	Chr16:88371320-88382819 (-)
AKR/J	MGP_AKRJ_G0022985	protein coding gene	Chr16:91040255-91051756 (-)
BALB/cJ	MGP_BALBcJ_G0023017	protein coding gene	Chr16:88898410-88909909 (-)
C3H/HeJ	MGP_C3HHeJ_G0022778	protein coding gene	Chr16:91616504-91628036 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023464	protein coding gene	Chr16:95699604-95711101 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020966	protein coding gene	Chr16:86068553-86079967 (-)
CAST/EiJ	MGP_CASTEiJ_G0022297	protein coding gene	Chr16:92178632-92189902 (-)
CBA/J	MGP_CBAJ_G0022747	protein coding gene	Chr16:99790136-99801430 (-)
DBA/2J	MGP_DBA2J_G0022881	protein coding gene	Chr16:88275294-88286793 (-)
FVB/NJ	MGP_FVBNJ_G0022855	protein coding gene	Chr16:87399847-87411346 (-)
LP/J	MGP_LPJ_G0022951	protein coding gene	Chr16:92405174-92416671 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022876	protein coding gene	Chr16:104333966-104347918 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023482	protein coding gene	Chr16:91560597-91573970 (-)
PWK/PhJ	MGP_PWKPhJ_G0022042	protein coding gene	Chr16:88454114-88467527 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021872	protein coding gene	Chr16:91123724-91135069 (-)
WSB/EiJ	MGP_WSBEiJ_G0022349	protein coding gene	Chr16:91804389-91818085 (-)

Human Ortholog

DONSON, DNA replication fork stabilization factor DONSON

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DONSON, DNA replication fork stabilization factor DONSON
Synonyms

B17, C21orf60, MIMIS, MISSLA
Links

HGNC:2993

NCBI Gene ID: 29980

neXtProt AC: NX_Q9NYP3

UniProt: Q9NYP3
Chr Location

21q22.11; chr21:33559542-33588706 (-) GRCh38

MGI Vertebrate Homology

Donson stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DONSON
Gene Tree

Donson

Diseases

2 with human DONSON associations

				Human Disease	Mouse Models
				microcephaly, short stature, and limb abnormalities IDs microcephaly, short stature, and limb abnormalities DOID:0081431 OMIM:617604 ORDO:572761
				microcephaly-micromelia syndrome IDs microcephaly-micromelia syndrome DOID:0081432 OMIM:251230 ORDO:572768

Click on a disease name to see all genes associated with that disease.

References

4 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
78 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

1
Spontaneous

1
Targeted

12
Genomic Mutations

9 involving Donson
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout is early embryonic lethal. Heterozygous knockout causes no observable phenotype.

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All GO Annotations

18
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

786
Tissues

75
cDNA Data

9
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase donson

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All Sequences

65
RefSeq

4
UniProt

10
CCDS

CCDS28330.1

Ensembl

ENSMUSG00000022960 (Evidence)
NCBI Gene

60364

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022960	Ensembl Gene Model \| MGI Sequence Detail	11963	C57BL/6J	± kb
transcript	ENSMUST00000023682	Ensembl \| MGI Sequence Detail	2365	Not Applicable
polypeptide	ENSMUSP00000023682	Ensembl \| MGI Sequence Detail	560	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000006638 protein downstream neighbor of Son

(term hierarchy)
InterPro Domains

IPR024861 Donson

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All nucleic 16

cDNA 11

Primer pair 3

Other 2

Microarray probesets 3

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MGI:1915899, MGI:2146495

Summaries

All 110

Developmental Gene Expression 5

Diseases 4

Gene Ontology 3

Phenotypes 78
Earliest

J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Donson:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142106	Chr16:91485679-91485690 (-)	-27 bp
Tssr142105	Chr16:91485597-91485662 (-)	28 bp
Tssr142104	Chr16:91482525-91482553 (-)	3,119 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24