Fignl1 MGI Mouse Gene Detail - MGI:1890648

Symbol

Fignl1
Name

fidgetin-like 1

Feature Type

protein coding gene
IDs

MGI:1890648
NCBI Gene: 60530
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:11737431-11758962 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 7.08 cM, cytoband A2
Mapping Data

4 experiments

SNPs within 2kb

656 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890648	protein coding gene	Chr11:11737429-11758962 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018046	protein coding gene	Chr11:9079945-9104104 (-)
A/J	MGP_AJ_G0018019	protein coding gene	Chr11:8762655-8784796 (-)
AKR/J	MGP_AKRJ_G0017983	protein coding gene	Chr11:9130450-9153072 (-)
BALB/cJ	MGP_BALBcJ_G0017987	protein coding gene	Chr11:8784045-8805167 (-)
C3H/HeJ	MGP_C3HHeJ_G0017800	protein coding gene	Chr11:9031842-9054245 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018439	protein coding gene	Chr11:9387924-9413650 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016097	protein coding gene	Chr11:8306299-8328813 (-)
CAST/EiJ	MGP_CASTEiJ_G0017362	protein coding gene	Chr11:9041583-9066811 (-)
CBA/J	MGP_CBAJ_G0017775	protein coding gene	Chr11:10060716-10090116 (-)
DBA/2J	MGP_DBA2J_G0017885	protein coding gene	Chr11:8695961-8718404 (-)
FVB/NJ	MGP_FVBNJ_G0017877	protein coding gene	Chr11:8606625-8627855 (-)
LP/J	MGP_LPJ_G0017956	protein coding gene	Chr11:9185205-9208175 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017903	protein coding gene	Chr11:9788109-9809497 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018480	protein coding gene	Chr11:9151285-9175889 (-)
PWK/PhJ	MGP_PWKPhJ_G0017142	protein coding gene	Chr11:8731068-8753988 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016939	protein coding gene	Chr11:8995528-9022827 (-)
WSB/EiJ	MGP_WSBEiJ_G0017416	protein coding gene	Chr11:8913584-8936026 (-)

Human Ortholog

FIGNL1, fidgetin like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FIGNL1, fidgetin like 1
Links

HGNC:13286

NCBI Gene ID: 63979

neXtProt AC: NX_Q6PIW4

UniProt: Q6PIW4
Chr Location

7p12.2; chr7:50444128-50450390 (-) GRCh38

MGI Vertebrate Homology

Fignl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FIGNL1
Gene Tree

Fignl1

Diseases

1 with human FIGNL1 associations

				Human Disease	Mouse Models
				nicotine dependence IDs nicotine dependence DOID:0050742 EFO:0003768 ICD10CM:F17 MESH:D014029 NCI:C54203 UMLS_CUI:C0028043

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 3 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Endonuclease-mediated

1
Gene trapped

35
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

61 strains or lines available

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

7
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FIGNL1

Xenbase fignl1

ZFIN fignl1

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All Sequences

77
RefSeq

29
UniProt

2
CCDS

CCDS24438.1

Ensembl

ENSMUSG00000035455 (Evidence)
NCBI Gene

60530

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035455	Ensembl Gene Model \| MGI Sequence Detail	21532	C57BL/6J	± kb
transcript	ENSMUST00000047689	Ensembl \| MGI Sequence Detail	2961	Not Applicable
polypeptide	ENSMUSP00000036932	Ensembl \| MGI Sequence Detail	683	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007523 fidgetin-like protein 1

(term hierarchy)
EC

3.6.4.-
InterPro Domains

IPR041569 AAA ATPase, AAA+ lid domain

IPR003593 AAA+ ATPase domain

IPR003960 ATPase, AAA-type, conserved site

IPR003959 ATPase, AAA-type, core

IPR047858 Fidgetin-like 1, ATPase domain

IPR050304 Microtubule-severing AAA ATPase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR015415 Spastin/Vps4, C-terminal

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All nucleic 15

cDNA 15

Microarray probesets 5

Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 10
Earliest

J:64964 Cox GA, et al., The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development. Nat Genet. 2000 Oct;26(2):198-202
Latest

J:359005 Zainu A, et al., FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading. Nat Commun. 2024 Aug 15;15(1):7015

TSS for Fignl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106878	Chr11:11758923-11758967 (-)	17 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24